Table 3

Regional blood flow and oxygen delivery during infusion of vasopressin in non-septic animals

Time

300 minutes

360 minutes

480 minutes

Portal vein (mL/kg per minute)^a,b

Group C

33 ± 3

32 ± 5

30 ± 4

Group V

33 ± 8

23 ± 4^c

25 ± 4^c

Hepatic artery (mL/kg per minute)^a

Group C

3.2 ± 1.7

3.4 ± 1.7

3.7 ± 1.7

Group V

4.4 ± 1.6

8.2 ± 3.1^c

8 ± 2.5^c

MBF liver (percentage)

Group C

133 ± 53

135 ± 61

122 ± 57

Group V

85 ± 22

75 ± 38

77 ± 44

MBF kidney (percentage)^a

Group C

96 ± 14

94 ± 20

96 ± 20

Group V

106 ± 15

86 ± 16^c

105 ± 15

MBF pancreas (percentage)^a

Group C

119 ± 14

108 ± 18^c

99 ± 17^c

Group V

110 ± 30

74 ± 15^c

76 ± 23^c

A continuous infusion of vasopressin (0.06 IU/kg per hour) was started at t = 300 minutes in group V. Animals in group C received intravenous saline only.

^ap < 0.01 time-group interaction groups V versus C: effect of vasopressin in control animals.

^bp < 0.05 Mann-Whitney test (area under curve): effect of vasopressin in non-septic versus septic animals.

^cp < 0.01 compared to t = 300 minutes.

Group C: non-septic control group. Group V: non-septic vasopressin control group. Hepatic artery: blood flow in the hepatic artery. MBF kidney: microcirculatory blood flow in the renal cortex. MBF pancreas: microcirculatory blood flow in the pancreas. MBF was measured by laser Doppler flowmetry and expressed as percentage of baseline. Portal vein: blood flow in the portal vein.

Krejci et al. Critical Care 2007 11:R129   doi:10.1186/cc6197