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Regional blood flow and oxygen delivery during infusion of vasopressin in non-septic animals |
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| Time |
300 minutes |
360 minutes |
480 minutes |
|
|
|
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| Portal vein (mL/kg per minute)a,b |
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| Group C |
33 ± 3 |
32 ± 5 |
30 ± 4 |
|
| Group V |
33 ± 8 |
23 ± 4c |
25 ± 4c |
|
| Hepatic artery (mL/kg per minute)a |
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| Group C |
3.2 ± 1.7 |
3.4 ± 1.7 |
3.7 ± 1.7 |
|
| Group V |
4.4 ± 1.6 |
8.2 ± 3.1c |
8 ± 2.5c |
|
| MBF liver (percentage) |
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| Group C |
133 ± 53 |
135 ± 61 |
122 ± 57 |
|
| Group V |
85 ± 22 |
75 ± 38 |
77 ± 44 |
|
| MBF kidney (percentage)a |
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| Group C |
96 ± 14 |
94 ± 20 |
96 ± 20 |
|
| Group V |
106 ± 15 |
86 ± 16c |
105 ± 15 |
|
| MBF pancreas (percentage)a |
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| Group C |
119 ± 14 |
108 ± 18c |
99 ± 17c |
|
| Group V |
110 ± 30 |
74 ± 15c |
76 ± 23c |
|
|
A continuous infusion of vasopressin (0.06 IU/kg per hour) was started at t = 300 minutes in group V. Animals in group C received intravenous saline only. ap < 0.01 time-group interaction groups V versus C: effect of vasopressin in control animals. bp < 0.05 Mann-Whitney test (area under curve): effect of vasopressin in non-septic versus septic animals. cp < 0.01 compared to t = 300 minutes. Group C: non-septic control group. Group V: non-septic vasopressin control group. Hepatic artery: blood flow in the hepatic artery. MBF kidney: microcirculatory blood flow in the renal cortex. MBF pancreas: microcirculatory blood flow in the pancreas. MBF was measured by laser Doppler flowmetry and expressed as percentage of baseline. Portal vein: blood flow in the portal vein. | ||||
Krejci et al. Critical Care 2007 11:R129 doi:10.1186/cc6197 |
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