This article is part of the supplement: Fourth International Symposium on Intensive Care and Emergency Medicine for Latin America
Serum lipids analysis in septic shock patients
Hospital Universitário da USP e Faculdade Medicina USP, São Paulo – SP, Brazil
Critical Care 2007, 11(Suppl 3):P19 doi:10.1186/cc5806
The electronic version of this article is the complete one and can be found online at: http://ccforum.com/content/11/S3/P19
| Published: | 19 June 2007 |
© 2007 BioMed Central Ltd
Objective
We conducted a prospective study to analyze serum lipids, glucose, triglycerides and C-reactive protein in septic shock patients to evaluate its relation with outcome.
Design
Prospective observational analysis of septic shock patients.
Setting
A 28-bed medico-surgical ICU.
Participants
Eighteen patients were analyzed.
Materials and methods
We collected blood samples for analysis on days 1, 3, 6, 9, 12 or until death.
Statistical analysis
All results are presented as the mean with standard deviation. For analysis we divided patients into survivors and nonsurvivors at day 12. We performed a paired Student t test for differences in continuous variables, and correlation coefficients were determined according to multiple-level regression analysis. P < 0.05 was considered significant.
Results
Our mortality rate was 60%. The two groups had similar APACHE II scores. At day 1 there were no statistical differences for any of the substances analyzed. From day 3 onward, significant differences were found between groups for total cholesterol, HDL fraction, triglycerides, glycemia and C-reactive protein. As independent variables, we found glycemia and triglycerides.
Conclusion
Low levels of cholesterolemia, HDL fraction, hyper-triglyceridemia and hyperglycemia were statistically significantly related to a poor prognosis.