Hemodynamic and metabolic features of a porcine systemic low flow state model

LCP Azevedo¹^,2, AT Maciel¹^,2, D Noritomi¹, GPP Schettino¹ and M Park¹^,2

¹Intensive Care Laboratory, Research and Education Institute, Hospital Sírio-Libanês, São Paulo – SP, Brazil

²Intensive Care Unit, Hospital das Clínicas, HCFMUSP, São Paulo – SP, Brazil

from Fourth International Symposium on Intensive Care and Emergency Medicine for Latin America
São Paulo, Brazil. 20–23 June 2007

Critical Care 2007, 11(Suppl 3):P6doi:10.1186/cc5793

The electronic version of this abstract is the complete one and can be found online at: http://ccforum.com/content/11/S3/P6

Published:

19 June 2007

Objective

To describe a new experimental systemic low flow state model induced by cardiac tamponade.

Methods

Ten Large White pigs (43 ± 5 kg) were instrumented with arterial and pulmonary catheters, cystostomy and splenectomy, and a latex balloon was inserted anterior to the heart. Pigs were randomized to a shock group or a control group. The shock group had the balloon inflated with 620 ± 344 ml to keep the mean arterial blood pressure at 45–55 mmHg (mean = 49 ± 4 mmHg) for 1 hour. Hemodynamic data were collected and shown as the mean ± SD. Two-way ANOVA was used with Bonferroni's correction.

Results

During shock, the SvO₂was 34 ± 8%, the heart rate was 173 ± 36 bpm, and the stroke volume was 18 ± 12 ml/min/beat. After shock, see Table 1.

Table 1.

Conclusion

In our model, transient cardiac tamponade caused persistent hypotension and cardiovascular dysfunction. Hyperthermia was an interesting finding in the last hours of the experiment in animals submitted to cardiac tamponade.

This article is part of the supplement: Fourth International Symposium on Intensive Care and Emergency Medicine for Latin America

Hemodynamic and metabolic features of a porcine systemic low flow state model

Objective

Methods

Results

Conclusion

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