Critical Care

official impact factor 4.60

This article is part of the supplement: Severe sepsis and drotrecogin alfa (activated)

The protein C pathway: implications for the design of the RESPOND study

Burkhard Vangerow*, Andrew F Shorr, Duncan Wyncoll, Jonathan Janes, David R Nelson and Konrad Reinhart

Critical Care 2007, 11(Suppl 5):S4 doi:10.1186/cc6155

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Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)

Andrew F Shorr, Jonathan M Janes, Antonio Artigas, Jyrki Tenhunen, Duncan LA Wyncoll, Emmanuelle Mercier, Bruno Francois, Jean-Louis Vincent, Burkhard Vangerow, Darell Heiselman, Amy G Leishman, Yajun E Zhu, Konrad Reinhart, Critical Care 2010, 14:R229 (21 December 2010)

Commentary   Free

Protein C as a surrogate end-point for clinical trials of sepsis

Kathleen D Liu, Michael A Matthay Critical Care 2008, 12:139 (24 April 2008)

Review   Free Highly Accessed

Recombinant human activated protein C: current insights into its mechanism of action

Marcel Levi, Tom van der Poll Critical Care 2007, 11(Suppl 5):S3 (19 December 2007)

Introduction   Free Highly Accessed

Introduction: severe sepsis and drotrecogin alfa (activated)

Antonio Artigas, Claude D Martin Critical Care 2007, 11(Suppl 5):S1 (19 December 2007)