Critical Care | Volume 12 Issue 1

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	Volume 12 Issue 1
	Comment
	Editorial Obituary: Professor John Henry, MBBS, FRCP, FFAEM (1939–2007) Allister Vale Critical Care 2008, 12:101 (11 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Sedation practice: is it time to wake up and embrace change? Kate Regan, Owen Boyd Critical Care 2008, 12:102 (8 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Targeting RAGE in sepsis Marieke AD van Zoelen, Tom van der Poll Critical Care 2008, 12:103 (11 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Nitric oxide, leukocytes and microvascular permeability: causality or bystanders? Balázs Hauser, Martin Matejovic, Peter Radermacher Critical Care 2008, 12:104 (16 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary An anti-inflammatory role for tranexamic acid in cardiac surgery? Heidi J Robertshaw Critical Care 2008, 12:105 (16 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Maintenance of tracheal tube cuff pressure: where are the limits? Miquel Ferrer, Antoni Torres Critical Care 2008, 12:106 (16 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies? Luzius A Steiner Critical Care 2008, 12:107 (18 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Procalcitonin in liver transplant patients – yet another stone turned Jens-Ulrik Jensen, Jens D Lundgren Critical Care 2008, 12:108 (22 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Effect of sepsis therapies on health-related quality of life Sara E Erickson, Greg S Martin Critical Care 2008, 12:109 (22 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Are platelets a 'forgotten' source of sepsis-induced myocardial depressing factor(s)? Alexandre Mebazaa Critical Care 2008, 12:110 (23 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Predictors of outcome in myxoedema coma Jennifer Beynon, Simeen Akhtar, Tara Kearney Critical Care 2008, 12:111 (23 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Recently published papers: Sepsis, glucose control and patient–doctor relationships Christopher Bouch, Gareth Williams Critical Care 2008, 12:112 (1 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Unmeasured anions: the unknown unknowns Bala Venkatesh, Thomas J Morgan Critical Care 2008, 12:113 (5 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Clostridium difficile: the increasingly difficult pathogen Aurora Pop-Vicas, Marguerite A Neill Critical Care 2008, 12:114 (7 February 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary More than skin deep: moisturizing body milk and Burkholderia cepacia Amy E Irwin, Connie Price Critical Care 2008, 12:115 (20 February 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Restoring normoglycaemia: not so harmless Jean-Charles Preiser Critical Care 2008, 12:116 (28 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review
	Review Clinical review: Major consequences of illicit drug consumption Robert J Devlin, John A Henry Critical Care 2008, 12:202 (8 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis Christian Bopp, Angelika Bierhaus, Stefan Hofer, Axel Bouchon, Peter P Nawroth, Eike Martin, Markus A Weigand Critical Care 2008, 12:201 (9 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: Clostridium difficile colitis Carolyn V Gould, L Clifford McDonald Critical Care 2008, 12:203 (18 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: Candida infections in the intensive care unit Marie Méan, Oscar Marchetti, Thierry Calandra Critical Care 2008, 12:204 (22 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams Augustine Tee, Paolo Calzavacca, Elisa Licari, Donna Goldsmith, Rinaldo Bellomo Critical Care 2008, 12:205 (23 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis – there is nothing more practical than a good theory Hülya Bayir, Valerian E Kagan Critical Care 2008, 12:206 (18 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Journal club critique PAC in FACTT: Time to PAC it in? Wissam Mansour, Eric B Milbrandt, Lillian L Emlet Critical Care 2008, 12:301 (6 February 2008) Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research
	Research Predictors of outcome in myxoedema coma: a study from a tertiary care centre Pinaki Dutta, Anil Bhansali, Shriq Masoodi, Sanjay Bhadada, Navneet Sharma, Rajesh Rajput Critical Care 2008, 12:R1 (3 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism John H Boyd, Edmond H Chau, Chiho Tokunanga, Ryon M Bateman, Greg Haljan, Ehsan Y Davani, Yinjin Wang, Keith R Walley Critical Care 2008, 12:R2 (3 January 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An animal model suggests site 117-133 of the fibrinogen gamma chain decreases cardiomyocyte contractility through binding the adhesion molecule ICAM-1, providing insight into pathologies characterised by heart failure and systemic inflammation.
	Research Diagnostic utility of B-type natriuretic peptide in critically ill patients with pulmonary edema: a prospective cohort study Joseph E Levitt, Ajeet G Vinayak, Brian K Gehlbach, Anne Pohlman, William Van Cleve, Jesse B Hall, John P Kress Critical Care 2008, 12:R3 (14 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Effects of plasma expansion with albumin and paracentesis on haemodynamics and kidney function in critically ill cirrhotic patients with tense ascites and hepatorenal syndrome: a prospective uncontrolled trial Andreas Umgelter, Wolfgang Reindl, Katrin S Wagner, Michael Franzen, Konrad Stock, Roland M Schmid, Wolfgang Huber Critical Care 2008, 12:R4 (15 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Impact of invasive fungal infection on outcomes of severe sepsis: a multicenter matched cohort study in critically ill surgical patients Guo-Hao Xie, Xiang-Ming Fang, Qiang Fang, Xin-Min Wu, Yu-Hong Jin, Jun-Lu Wang, Qu-Lian Guo, Miao-Ning Gu, Qiu-Ping Xu, Dong-Xin Wang, Shang-Long Yao, Shi-Ying Yuan, Zhao-Hui Du, Yun-Bo Sun, Hai-Hong Wang, Shui-Jing Wu, Bao-Li Cheng Critical Care 2008, 12:R5 (16 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Invasive fungal infection is frequent in patients with severe sepsis in surgical intensive care units and associated with excess risk of mortality, longer hospital stays, and greater use of medical resources.
	Research Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates Jin Huh, Chae-Man Lim, Younsuck Koh, Yeon Oh, Tae Shim, Sang Lee, Woo Kim, Dong Kim, Won Kim, Sang-Bum Hong Critical Care 2008, 12:R6 (19 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in bronchoalveolar lavage fluid is a potential marker for pneumonia due to extracellular bacteria in patients with bilateral lung infiltrates.
	Research Alveolar recruitment can be predicted from airway pressure-lung volume loops: an experimental study in a porcine acute lung injury model Jacob Koefoed-Nielsen, Niels Nielsen, Anders J Kjærgaard, Anders Larsson Critical Care 2008, 12:R7 (21 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A pressure volume-loop derived parameter predicted changes in lung mechanics better than changes in gas exchange, suggesting this measure could predict the effectiveness of alveolar recruitment in acute lung injury.
	Research Biphasic onset of splenic apoptosis following hemorrhagic shock: critical implications for Bax, Bcl-2, and Mcl-1 proteins Arwed Hostmann, Kerstin Jasse, Gundula Schulze-Tanzil, Yohan Robinson, Andreas Oberholzer, Wolfgang Ertel, Sven K Tschoeke Critical Care 2008, 12:R8 (22 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hemorrhagic shock induces apoptotic changes in spleen through a biphasic caspase-dependent mechanism mediated by mitochondrial proteins Bax, Bcl-2 and Mcl-1, thereby promoting post-traumatic immunosuppression, studies in mice suggest.
	Research Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome Nazim Nathani, Gavin D Perkins, William Tunnicliffe, Nick Murphy, Mav Manji, David R Thickett Critical Care 2008, 12:R12 (23 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage Florian Schlenk, Daniela Graetz, Alexandra Nagel, Maren Schmidt, Asita S Sarrafzadeh Critical Care 2008, 12:R9 (24 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo Stephanie Nonas, Anna A Birukova, Panfeng Fu, Jungjie Xing, Santipongse Chatchavalvanich, Valery N Bochkov, Norbert Leitinger, Joe GN Garcia, Konstantin G Birukov Critical Care 2008, 12:R27 (24 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Critical care management and outcome of severe Pneumocystis pneumonia in patients with and without HIV infection Xavier Monnet, Emmanuelle Vidal-Petiot, David Osman, Olfa Hamzaoui, Antoine Durrbach, Cécile Goujard, Corinne Miceli, Patrice Bourée, Christian Richard Critical Care 2008, 12:R28 (25 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Moisturizing body milk as a reservoir of Burkholderia cepacia: outbreak of nosocomial infection in a multidisciplinary intensive care unit Francisco Álvarez-Lerma, Elena Maull, Roser Terradas, Concepción Segura, Irene Planells, Pere Coll, Hernando Knobel, Antonia Vázquez Critical Care 2008, 12:R10 (31 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Contaminated moisturizing body milk caused life-threatening infections in five critically ill patients, supporting recommendations against the use of hospital cosmetics for which there is no guarantee of sterilization.
	Research Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia Renato Seligman, Jana Papassotiriou, Nils G Morgenthaler, Michael Meisner, Paulo JZ Teixeira Critical Care 2008, 12:R11 (5 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Copeptin levels increase progressively with the severity of sepsis and are independent predictors of mortality in ventilator-associated pneumonia, in a prospective observational cohort study of 71 patients.
	Research Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis Paulo S Martins, Milena KC Brunialti, Leandro SW Martos, Flavia R Machado, Murillo S Assunçao, Sergio Blecher, Reinaldo Salomao Critical Care 2008, 12:R25 (13 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Withholding and withdrawing life-sustaining treatment: a comparative study of the ethical reasoning of physicians and the general public Anders Rydvall, Niels Lynöe Critical Care 2008, 12:R13 (15 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Differing opinions between the public and physicians over the reasonable amount of care provided to severely ill patients suggests that the healthcare profession should be more aware of the general public's expectations.
	Research Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data Christian von Heymann, Sven Jonas, Claudia Spies, Klaus-Dieter Wernecke, Sabine Ziemer, Detlev Janssen, Jürgen Koscielny Critical Care 2008, 12:R14 (15 February 2008) Abstract \| Full text \| PDF \| PubMed
	Research Comparison of different pain scoring systems in critically ill patients in a general ICU Sabine JGM Ahlers, Laura van Gulik, Aletta M van der Veen, Hendricus PA van Dongen, Peter Bruins, Svetlana V Belitser, Anthonius de Boer, Dick Tibboel, Catherijne AJ Knibbe Critical Care 2008, 12:R15 (16 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary As nurses often underestimate pain levels, ICU patients should rate their own pain whenever possible, while the attending nurse involved in the patient's daily care should score those who are unresponsive.
	Research A comparison of the CAM-ICU and the NEECHAM Confusion Scale in intensive care delirium assessment: an observational study in non-intubated patients Bart Van Rompaey, Marieke J Schuurmans, Lillie M Shortridge-Baggett, Steven Truijen, Monique Elseviers, Leo Bossaert Critical Care 2008, 12:R16 (18 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor Djamel Mokart, Eric Kipnis, Pierre Guerre-Berthelot, Norbert Vey, Christian Capo, Antoine Sannini, Jean-Paul Brun, Jean-Louis Blache, Jean-Louis Mege, Didier Blaise, Benoit P Guery Critical Care 2008, 12:R17 (18 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Echocardiographic assessment of pulmonary artery occlusion pressure in ventilated patients: a transoesophageal study Philippe Vignon, Ali AitHssain, Bruno François, Pierre-Marie Preux, Nicolas Pichon, Marc Clavel, Jean-Pierre Frat, Hervé Gastinne Critical Care 2008, 12:R18 (19 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Research Outcomes and costs of blunt trauma in England and Wales Michael C Christensen, Saxon Ridley, Fiona E Lecky, Vicki Munro, Stephen Morris Critical Care 2008, 12:R23 (19 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Combined didactic and scenario-based education improves the ability of intensive care unit staff to recognize delirium at the bedside John W Devlin, Francois Marquis, Richard R Riker, Tracey Robbins, Erik Garpestad, Jeffrey J Fong, Dorothy Didomenico, Yoanna Skrobik Critical Care 2008, 12:R19 (21 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The combination of a lecture and case scenario exercises appears to rapidly improve the capacity for ICU nurses to perform delirium assessments in a standardised fashion without any reduction in accuracy.
	Research Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia Stig Müller, Ole-Jakob How, Stig Hermansen, Thor Stenberg, Georg Sager, Truls Myrmel Critical Care 2008, 12:R20 (21 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Arginin vasopressin induces a major reduction in vital organ blood flow after transient cardiac ischemia, indicating a potentially harmful effect in patients with heart failure or cardiogenic shock.
	Research 'One patient amongst many': a qualitative analysis of intensive care unit patients' experiences of transferring to the general ward Kate Field, Suman Prinjha, Kathy Rowan Critical Care 2008, 12:R21 (22 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study Lukas Schwake, Judith Streit, Lutz Edler, Jens Encke, Wolfgang Stremmel, Thomas Junghanss Critical Care 2008, 12:R22 (22 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Glycemic penalty index for adequately assessing and comparing different blood glucose control algorithms Tom Van Herpe, Jos De Brabanter, Martine Beullens, Bart De Moor, Greet Van den Berghe Critical Care 2008, 12:R24 (26 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Determinants of tracheostomy decannulation: an international survey Henry Stelfox, Claudia Crimi, Lorenzo Berra, Alberto Noto, Ulrich Schmidt, Luca M Bigatello, Dean Hess Critical Care 2008, 12:R26 (26 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Intensive insulin therapy and mortality in critically ill patients Miriam M Treggiari, Veena Karir, N David Yanez, Noel S Weiss, Stephen Daniel, Steven A Deem Critical Care 2008, 12:R29 (29 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intensive insulin therapy was not associated with a reduction in hospital mortality and was potentially harmful to some subgroups in a mixed cohort study of more than 10,000 critically ill patients.
	Research Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management The Irish Critical Care Trials Group Critical Care 2008, 12:R30 (29 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Mild hypothermia during advanced life support: a preliminary study in out-of-hospital cardiac arrest Cédric Bruel, Jean-Jacques Parienti, William Marie, Xavier Arrot, Cédric Daubin, Damien Du Cheyron, Massimo Massetti, Pierre Charbonneau Critical Care 2008, 12:R31 (29 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Correspondence
	Letter Cardiac arrest following a glucose 30% bolus: what happened? Philippe Goutorbe, Nadia Kenane, Julien Bordes, Christophe Jego, Ambroise Montcriol, Eric Meaudre Critical Care 2008, 12:401 (16 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Outcome research in meningococcal septic shock Corinne Buysse, Lindy Vermunt, Elisabeth Utens, Koen Joosten, Jan Hazelzet Critical Care 2008, 12:402 (17 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Clinical value of an arterial pressure-based cardiac output measurement device Joris Lemson, Johannes G van der Hoeven Critical Care 2008, 12:403 (25 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Evidence-based approach to intensive care unit management: need for improvement Anders Ersson, Michelle Chew Critical Care 2008, 12:404 (25 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Increased bleeding risk associated with the use of recombinant human activated protein C in patients with advanced liver disease Adam Keene, Thomas Kawano, Syed Anees, Julie Chen Critical Care 2008, 12:405 (11 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Extrapulmonary effects of nitric oxide inhalation therapy: time to consider new dosing regimes? Jon O Lundberg, Eddie Weitzberg Critical Care 2008, 12:406 (11 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Clinical relevance of the PaO₂/FiO₂ratio Mohamad F El-Khatib, Gassan W Jamaleddine Critical Care 2008, 12:407 (14 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter The quest for optimal positive end-expiratory pressure continues Dick Markhorst, Martin Kneyber, Marc van Heerde Critical Care 2008, 12:408 (21 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter A persistently elevated C-reactive protein level in pneumonia may indicate empyema Michael Eisenhut Critical Care 2008, 12:409 (27 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter How much insulin is acceptable following aneurysmal subarachnoid hemorrhage? John F Stover Critical Care 2008, 12:410 (27 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter A message in a bottle: a case report Felix Mehrhof, Achim Joerres, Rainer Dietz, Michael Oppert Critical Care 2008, 12:411 (27 February 2008) Abstract \| Full text \| PDF \| PubMed

	Volume 12 Issue 1
	Comment
	Editorial Obituary: Professor John Henry, MBBS, FRCP, FFAEM (1939–2007) Allister Vale Critical Care 2008, 12:101 (11 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Sedation practice: is it time to wake up and embrace change? Kate Regan, Owen Boyd Critical Care 2008, 12:102 (8 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Targeting RAGE in sepsis Marieke AD van Zoelen, Tom van der Poll Critical Care 2008, 12:103 (11 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Nitric oxide, leukocytes and microvascular permeability: causality or bystanders? Balázs Hauser, Martin Matejovic, Peter Radermacher Critical Care 2008, 12:104 (16 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary An anti-inflammatory role for tranexamic acid in cardiac surgery? Heidi J Robertshaw Critical Care 2008, 12:105 (16 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Maintenance of tracheal tube cuff pressure: where are the limits? Miquel Ferrer, Antoni Torres Critical Care 2008, 12:106 (16 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies? Luzius A Steiner Critical Care 2008, 12:107 (18 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Procalcitonin in liver transplant patients – yet another stone turned Jens-Ulrik Jensen, Jens D Lundgren Critical Care 2008, 12:108 (22 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Effect of sepsis therapies on health-related quality of life Sara E Erickson, Greg S Martin Critical Care 2008, 12:109 (22 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Are platelets a 'forgotten' source of sepsis-induced myocardial depressing factor(s)? Alexandre Mebazaa Critical Care 2008, 12:110 (23 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Predictors of outcome in myxoedema coma Jennifer Beynon, Simeen Akhtar, Tara Kearney Critical Care 2008, 12:111 (23 January 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Recently published papers: Sepsis, glucose control and patient–doctor relationships Christopher Bouch, Gareth Williams Critical Care 2008, 12:112 (1 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Unmeasured anions: the unknown unknowns Bala Venkatesh, Thomas J Morgan Critical Care 2008, 12:113 (5 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Clostridium difficile: the increasingly difficult pathogen Aurora Pop-Vicas, Marguerite A Neill Critical Care 2008, 12:114 (7 February 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary More than skin deep: moisturizing body milk and Burkholderia cepacia Amy E Irwin, Connie Price Critical Care 2008, 12:115 (20 February 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Restoring normoglycaemia: not so harmless Jean-Charles Preiser Critical Care 2008, 12:116 (28 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review
	Review Clinical review: Major consequences of illicit drug consumption Robert J Devlin, John A Henry Critical Care 2008, 12:202 (8 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis Christian Bopp, Angelika Bierhaus, Stefan Hofer, Axel Bouchon, Peter P Nawroth, Eike Martin, Markus A Weigand Critical Care 2008, 12:201 (9 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: Clostridium difficile colitis Carolyn V Gould, L Clifford McDonald Critical Care 2008, 12:203 (18 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: Candida infections in the intensive care unit Marie Méan, Oscar Marchetti, Thierry Calandra Critical Care 2008, 12:204 (22 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams Augustine Tee, Paolo Calzavacca, Elisa Licari, Donna Goldsmith, Rinaldo Bellomo Critical Care 2008, 12:205 (23 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis – there is nothing more practical than a good theory Hülya Bayir, Valerian E Kagan Critical Care 2008, 12:206 (18 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Journal club critique PAC in FACTT: Time to PAC it in? Wissam Mansour, Eric B Milbrandt, Lillian L Emlet Critical Care 2008, 12:301 (6 February 2008) Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research
	Research Predictors of outcome in myxoedema coma: a study from a tertiary care centre Pinaki Dutta, Anil Bhansali, Shriq Masoodi, Sanjay Bhadada, Navneet Sharma, Rajesh Rajput Critical Care 2008, 12:R1 (3 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism John H Boyd, Edmond H Chau, Chiho Tokunanga, Ryon M Bateman, Greg Haljan, Ehsan Y Davani, Yinjin Wang, Keith R Walley Critical Care 2008, 12:R2 (3 January 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An animal model suggests site 117-133 of the fibrinogen gamma chain decreases cardiomyocyte contractility through binding the adhesion molecule ICAM-1, providing insight into pathologies characterised by heart failure and systemic inflammation.
	Research Diagnostic utility of B-type natriuretic peptide in critically ill patients with pulmonary edema: a prospective cohort study Joseph E Levitt, Ajeet G Vinayak, Brian K Gehlbach, Anne Pohlman, William Van Cleve, Jesse B Hall, John P Kress Critical Care 2008, 12:R3 (14 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Effects of plasma expansion with albumin and paracentesis on haemodynamics and kidney function in critically ill cirrhotic patients with tense ascites and hepatorenal syndrome: a prospective uncontrolled trial Andreas Umgelter, Wolfgang Reindl, Katrin S Wagner, Michael Franzen, Konrad Stock, Roland M Schmid, Wolfgang Huber Critical Care 2008, 12:R4 (15 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Impact of invasive fungal infection on outcomes of severe sepsis: a multicenter matched cohort study in critically ill surgical patients Guo-Hao Xie, Xiang-Ming Fang, Qiang Fang, Xin-Min Wu, Yu-Hong Jin, Jun-Lu Wang, Qu-Lian Guo, Miao-Ning Gu, Qiu-Ping Xu, Dong-Xin Wang, Shang-Long Yao, Shi-Ying Yuan, Zhao-Hui Du, Yun-Bo Sun, Hai-Hong Wang, Shui-Jing Wu, Bao-Li Cheng Critical Care 2008, 12:R5 (16 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Invasive fungal infection is frequent in patients with severe sepsis in surgical intensive care units and associated with excess risk of mortality, longer hospital stays, and greater use of medical resources.
	Research Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates Jin Huh, Chae-Man Lim, Younsuck Koh, Yeon Oh, Tae Shim, Sang Lee, Woo Kim, Dong Kim, Won Kim, Sang-Bum Hong Critical Care 2008, 12:R6 (19 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in bronchoalveolar lavage fluid is a potential marker for pneumonia due to extracellular bacteria in patients with bilateral lung infiltrates.
	Research Alveolar recruitment can be predicted from airway pressure-lung volume loops: an experimental study in a porcine acute lung injury model Jacob Koefoed-Nielsen, Niels Nielsen, Anders J Kjærgaard, Anders Larsson Critical Care 2008, 12:R7 (21 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A pressure volume-loop derived parameter predicted changes in lung mechanics better than changes in gas exchange, suggesting this measure could predict the effectiveness of alveolar recruitment in acute lung injury.
	Research Biphasic onset of splenic apoptosis following hemorrhagic shock: critical implications for Bax, Bcl-2, and Mcl-1 proteins Arwed Hostmann, Kerstin Jasse, Gundula Schulze-Tanzil, Yohan Robinson, Andreas Oberholzer, Wolfgang Ertel, Sven K Tschoeke Critical Care 2008, 12:R8 (22 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hemorrhagic shock induces apoptotic changes in spleen through a biphasic caspase-dependent mechanism mediated by mitochondrial proteins Bax, Bcl-2 and Mcl-1, thereby promoting post-traumatic immunosuppression, studies in mice suggest.
	Research Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome Nazim Nathani, Gavin D Perkins, William Tunnicliffe, Nick Murphy, Mav Manji, David R Thickett Critical Care 2008, 12:R12 (23 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage Florian Schlenk, Daniela Graetz, Alexandra Nagel, Maren Schmidt, Asita S Sarrafzadeh Critical Care 2008, 12:R9 (24 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo Stephanie Nonas, Anna A Birukova, Panfeng Fu, Jungjie Xing, Santipongse Chatchavalvanich, Valery N Bochkov, Norbert Leitinger, Joe GN Garcia, Konstantin G Birukov Critical Care 2008, 12:R27 (24 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Critical care management and outcome of severe Pneumocystis pneumonia in patients with and without HIV infection Xavier Monnet, Emmanuelle Vidal-Petiot, David Osman, Olfa Hamzaoui, Antoine Durrbach, Cécile Goujard, Corinne Miceli, Patrice Bourée, Christian Richard Critical Care 2008, 12:R28 (25 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Moisturizing body milk as a reservoir of Burkholderia cepacia: outbreak of nosocomial infection in a multidisciplinary intensive care unit Francisco Álvarez-Lerma, Elena Maull, Roser Terradas, Concepción Segura, Irene Planells, Pere Coll, Hernando Knobel, Antonia Vázquez Critical Care 2008, 12:R10 (31 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Contaminated moisturizing body milk caused life-threatening infections in five critically ill patients, supporting recommendations against the use of hospital cosmetics for which there is no guarantee of sterilization.
	Research Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia Renato Seligman, Jana Papassotiriou, Nils G Morgenthaler, Michael Meisner, Paulo JZ Teixeira Critical Care 2008, 12:R11 (5 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Copeptin levels increase progressively with the severity of sepsis and are independent predictors of mortality in ventilator-associated pneumonia, in a prospective observational cohort study of 71 patients.
	Research Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis Paulo S Martins, Milena KC Brunialti, Leandro SW Martos, Flavia R Machado, Murillo S Assunçao, Sergio Blecher, Reinaldo Salomao Critical Care 2008, 12:R25 (13 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Withholding and withdrawing life-sustaining treatment: a comparative study of the ethical reasoning of physicians and the general public Anders Rydvall, Niels Lynöe Critical Care 2008, 12:R13 (15 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Differing opinions between the public and physicians over the reasonable amount of care provided to severely ill patients suggests that the healthcare profession should be more aware of the general public's expectations.
	Research Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data Christian von Heymann, Sven Jonas, Claudia Spies, Klaus-Dieter Wernecke, Sabine Ziemer, Detlev Janssen, Jürgen Koscielny Critical Care 2008, 12:R14 (15 February 2008) Abstract \| Full text \| PDF \| PubMed
	Research Comparison of different pain scoring systems in critically ill patients in a general ICU Sabine JGM Ahlers, Laura van Gulik, Aletta M van der Veen, Hendricus PA van Dongen, Peter Bruins, Svetlana V Belitser, Anthonius de Boer, Dick Tibboel, Catherijne AJ Knibbe Critical Care 2008, 12:R15 (16 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary As nurses often underestimate pain levels, ICU patients should rate their own pain whenever possible, while the attending nurse involved in the patient's daily care should score those who are unresponsive.
	Research A comparison of the CAM-ICU and the NEECHAM Confusion Scale in intensive care delirium assessment: an observational study in non-intubated patients Bart Van Rompaey, Marieke J Schuurmans, Lillie M Shortridge-Baggett, Steven Truijen, Monique Elseviers, Leo Bossaert Critical Care 2008, 12:R16 (18 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor Djamel Mokart, Eric Kipnis, Pierre Guerre-Berthelot, Norbert Vey, Christian Capo, Antoine Sannini, Jean-Paul Brun, Jean-Louis Blache, Jean-Louis Mege, Didier Blaise, Benoit P Guery Critical Care 2008, 12:R17 (18 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Echocardiographic assessment of pulmonary artery occlusion pressure in ventilated patients: a transoesophageal study Philippe Vignon, Ali AitHssain, Bruno François, Pierre-Marie Preux, Nicolas Pichon, Marc Clavel, Jean-Pierre Frat, Hervé Gastinne Critical Care 2008, 12:R18 (19 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Research Outcomes and costs of blunt trauma in England and Wales Michael C Christensen, Saxon Ridley, Fiona E Lecky, Vicki Munro, Stephen Morris Critical Care 2008, 12:R23 (19 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Combined didactic and scenario-based education improves the ability of intensive care unit staff to recognize delirium at the bedside John W Devlin, Francois Marquis, Richard R Riker, Tracey Robbins, Erik Garpestad, Jeffrey J Fong, Dorothy Didomenico, Yoanna Skrobik Critical Care 2008, 12:R19 (21 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The combination of a lecture and case scenario exercises appears to rapidly improve the capacity for ICU nurses to perform delirium assessments in a standardised fashion without any reduction in accuracy.
	Research Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia Stig Müller, Ole-Jakob How, Stig Hermansen, Thor Stenberg, Georg Sager, Truls Myrmel Critical Care 2008, 12:R20 (21 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Arginin vasopressin induces a major reduction in vital organ blood flow after transient cardiac ischemia, indicating a potentially harmful effect in patients with heart failure or cardiogenic shock.
	Research 'One patient amongst many': a qualitative analysis of intensive care unit patients' experiences of transferring to the general ward Kate Field, Suman Prinjha, Kathy Rowan Critical Care 2008, 12:R21 (22 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study Lukas Schwake, Judith Streit, Lutz Edler, Jens Encke, Wolfgang Stremmel, Thomas Junghanss Critical Care 2008, 12:R22 (22 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Glycemic penalty index for adequately assessing and comparing different blood glucose control algorithms Tom Van Herpe, Jos De Brabanter, Martine Beullens, Bart De Moor, Greet Van den Berghe Critical Care 2008, 12:R24 (26 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Determinants of tracheostomy decannulation: an international survey Henry Stelfox, Claudia Crimi, Lorenzo Berra, Alberto Noto, Ulrich Schmidt, Luca M Bigatello, Dean Hess Critical Care 2008, 12:R26 (26 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Intensive insulin therapy and mortality in critically ill patients Miriam M Treggiari, Veena Karir, N David Yanez, Noel S Weiss, Stephen Daniel, Steven A Deem Critical Care 2008, 12:R29 (29 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intensive insulin therapy was not associated with a reduction in hospital mortality and was potentially harmful to some subgroups in a mixed cohort study of more than 10,000 critically ill patients.
	Research Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management The Irish Critical Care Trials Group Critical Care 2008, 12:R30 (29 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Mild hypothermia during advanced life support: a preliminary study in out-of-hospital cardiac arrest Cédric Bruel, Jean-Jacques Parienti, William Marie, Xavier Arrot, Cédric Daubin, Damien Du Cheyron, Massimo Massetti, Pierre Charbonneau Critical Care 2008, 12:R31 (29 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Correspondence
	Letter Cardiac arrest following a glucose 30% bolus: what happened? Philippe Goutorbe, Nadia Kenane, Julien Bordes, Christophe Jego, Ambroise Montcriol, Eric Meaudre Critical Care 2008, 12:401 (16 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Outcome research in meningococcal septic shock Corinne Buysse, Lindy Vermunt, Elisabeth Utens, Koen Joosten, Jan Hazelzet Critical Care 2008, 12:402 (17 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Clinical value of an arterial pressure-based cardiac output measurement device Joris Lemson, Johannes G van der Hoeven Critical Care 2008, 12:403 (25 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Evidence-based approach to intensive care unit management: need for improvement Anders Ersson, Michelle Chew Critical Care 2008, 12:404 (25 January 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Increased bleeding risk associated with the use of recombinant human activated protein C in patients with advanced liver disease Adam Keene, Thomas Kawano, Syed Anees, Julie Chen Critical Care 2008, 12:405 (11 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Extrapulmonary effects of nitric oxide inhalation therapy: time to consider new dosing regimes? Jon O Lundberg, Eddie Weitzberg Critical Care 2008, 12:406 (11 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Clinical relevance of the PaO₂/FiO₂ratio Mohamad F El-Khatib, Gassan W Jamaleddine Critical Care 2008, 12:407 (14 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter The quest for optimal positive end-expiratory pressure continues Dick Markhorst, Martin Kneyber, Marc van Heerde Critical Care 2008, 12:408 (21 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter A persistently elevated C-reactive protein level in pneumonia may indicate empyema Michael Eisenhut Critical Care 2008, 12:409 (27 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter How much insulin is acceptable following aneurysmal subarachnoid hemorrhage? John F Stover Critical Care 2008, 12:410 (27 February 2008) Abstract \| Full text \| PDF \| PubMed
	Letter A message in a bottle: a case report Felix Mehrhof, Achim Joerres, Rainer Dietz, Michael Oppert Critical Care 2008, 12:411 (27 February 2008) Abstract \| Full text \| PDF \| PubMed

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