Commentary

Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies?

Luzius A Steiner

Author Affiliations

Department of Anaesthesia, University Hospital Basel, Spitalstrasse 21, CH-4031 Basel, Switzerland

Critical Care 2008, 12:107 doi:10.1186/cc6217


See related research by Thees et al., http://ccforum.com/content/11/6/R123

Published: 18 January 2008

Abstract

Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform. It is important to interpret the results of such studies in view of our limited ability to diagnose and quantify brain dysfunction and to consider our limited understanding of the mechanisms that lead to or are associated with brain dysfunction in sepsis.