Unmeasured anions: the unknown unknowns

doi:10.1186/cc6768

Critical Care

Volume 12
Issue 1

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Commentary

Unmeasured anions: the unknown unknowns

Bala Venkatesh¹ and Thomas J Morgan²

¹Department of Intensive Care, Princess Alexandra and Wesley Hospitals, University of Queensland, Queensland, QLD 4102, Australia

²Department of Intensive Care, Mater Misericordiae Hospital, South Brisbane, Queensland, QLD 4101, Australia

author email corresponding author email

Critical Care 2008, 12:113doi:10.1186/cc6768


Published:	5 February 2008

See related research by Bruegger et al., http://ccforum.com/content/11/6/R130 and see related letter by Moviat et al., http://ccforum.com/content/12/2/416

Abstract

Evidence is emerging that elevated concentrations of the intermediates of the citric acid cycle may contribute to unmeasured anions in critical illness. Both the anion gap and the strong ion gap are used as scanning tools for recognition of these anions. The mechanisms underlying these elevations and their significance require further clarification.