Critical Care

official impact factor 4.60

Commentary

Clostridium difficile: the increasingly difficult pathogen

Aurora Pop-Vicas* and Marguerite A Neill

Author Affiliations

Warren Alpert Medical School, Brown University, Division of Infectious Diseases, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USA

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Critical Care 2008, 12:114 doi:10.1186/cc6773

Published: 7 February 2008

Abstract

The epidemiology of Clostridium difficile infection is changing as a result of the epidemic spread of the hypervirulent North American Pulsefield type 1 strain. Clinicians are likely to encounter this disease more frequently than ever in their practice, and should be familiar with the updates in its diagnosis and treatment.