Restoring normoglycaemia: not so harmless
Department of General Intensive Care, University Hospital Centre, University of Liege, Domaine Universitaire du Sart Tilman – B 35, 4000 Liege, Belgium
Critical Care 2008, 12:116 doi:10.1186/cc6787Published: 28 February 2008
Three independent studies of tight glucose control were recently stopped prematurely due to an excess mortality in the intensive treatment arm. This commentary briefly discusses the potential mechanisms and reminds the potential benefits of physiological stress hyperglycemia.