Clinical relevance of the PaO2/FiO2 ratio
1 American University of Beirut, PO Box 11-0236, Beirut 1107-2020 Lebanon
2 SUNY, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York 11203, USA
Critical Care 2008, 12:407 doi:10.1186/cc6777
See related research by Karbing et al., http://ccforum.com/content/11/6/R118Published: 14 February 2008
First paragraph (this article has no abstract)
We read with interest the report by Karbing and coworkers  in which they assess the clinical relevance of variation in the arterial oxygen tension (PaO2)/fractional inspired oxygen (FiO2) ratio, a widely used oxygenation index, alongside changes in FiO2. In mechanically ventilated and spontaneously breathing patients, they showed that the clinical utility of PaO2/FiO2 ratio is doubtful unless the FiO2 level at which the PaO2/FiO2 ratio is measured is specified. They included data from 28 mechanically ventilated patients and from an additional eight mechanically ventilated patients at one or two different positive end-expiratory pressure (PEEP) settings.