Table 5 |
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|
Comparison between severe septic patients with and without IFI in the matched cohort study |
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|
Variable |
Severe sepsis patients with IFI (n = 60) |
Severe sepsis patients without IFI (n = 60) |
P value |
|
|
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|
Baseline descriptors |
|||
|
|
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|
Age (years; mean [IQR]) |
67.5 (52.25–75.75) |
68 (54–74) |
NS |
|
Admission APACHE II score (mean [IQR]) |
20 (16.25–25) |
20 (16.25–23.75) |
NS |
|
Admission SOFA score (mean [IQR]) |
8 (6–10.75) |
8 (5–12) |
NS |
|
Co-morbidity (n [%]) |
47 (78.3%) |
48 (80.0%) |
NS |
|
Cancer (n [%]) |
9 (15.0%) |
11 (18.3%) |
NS |
|
Diabetes mellitus (n [%]) |
10 (16.7%) |
9 (15.0%) |
NS |
|
Interventions |
|||
|
Mechanical ventilation (n [%]) |
49 (81.7%) |
24 (40.0%) |
<0.001 |
|
Central venous catheterization (n [%]) |
51 (85.0%) |
35 (58.3%) |
<0.001 |
|
Urinary catheterization (n [%]) |
58 (96.7%) |
36 (60.0%) |
<0.001 |
|
Arterial catheterization (n [%]) |
41 (68.3%) |
35 (58.3%) |
NS |
|
Total parenteral nutrition (n [%]) |
35 (58.3%) |
23 (38.3%) |
0.036 |
|
Corticosteroids or immunodepressant drugs (n [%]) |
13 (21.7%) |
16 (26.7%) |
NS |
|
Renal replacement therapy (n [%]) |
12 (20.0%) |
11 (18.3%) |
NS |
|
Outcomes |
|||
|
ICU LOS (days; mean [IQR]) |
17.5 (10–31) |
6.5 (3–10) |
<0.001 |
|
Hospital LOS (days; mean [IQR]) |
30 (19.25–50) |
20 (10.25–38.5) |
0.020 |
|
Mean daily costs ($; mean ± SD) |
592 ± 326 |
469 ± 396 |
NS |
|
Hospital costs ($; mean ± SD) |
17,951 ± 15,470 |
10,023 ± 12,347 |
0.038 |
|
Hospital mortality (n [%]) |
42 (70.0%) |
42 (50.0%) |
0.023 |
|
|
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|
APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; IQR, interquartile range; IFI, invasive fungal infection; LOS, length of stay; NS, not significant; SD, standard deviation; SOFA, Sequential Organ Failure Assessment. |
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|
Xie et al. Critical Care 2008 12:R5 doi:10.1186/cc6766 |
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