Critical Care | Volume 12 Issue 2

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	Volume 12 Issue 2
	Comment
	Editorial Relaunching the Pro–Con section at Critical Care Thomas E Stewart Critical Care 2008, 12:140 (25 April 2008) Abstract \| Full text \| PDF
	Commentary Copeptin: a new and promising diagnostic and prognostic marker Mira Katan, Beat Müller, Mirjam Christ-Crain Critical Care 2008, 12:117 (6 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Cardiovascular and metabolic responses to catecholamine and sepsis prognosis: a ubiquitous phenomenon? Solène Collin, Nacira Sennoun, Bruno Levy Critical Care 2008, 12:118 (17 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Towards goal-directed therapy of hepatorenal syndrome: we have the tools but we need the trials Rajeshwar P Mookerjee, Rajiv Jalan Critical Care 2008, 12:119 (19 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Recently published papers: Sepsis – guidelines, treatment and novel approaches Navneet Kalsi, Lui G Forni Critical Care 2008, 12:120 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary KL-6 in acute lung injury: will it leave its mark? Murali Shyamsundar, Danny F McAuley Critical Care 2008, 12:121 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Lost in translation? The pursuit of lung-protective ventilation Andrew T Jones Critical Care 2008, 12:122 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Optimal vasopressor drug therapy during resuscitation Joseph P Ornato Critical Care 2008, 12:123 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Insulin, intracerebral glucose and bedside biochemical monitoring utilizing microdialysis Carl-Henrik Nordström Critical Care 2008, 12:124 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Knowing who would respond to a recruitment maneuver before actually doing it – this might be a way to go Ralf Kuhlen Critical Care 2008, 12:125 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Circulating pro-apoptotic mediators in burn septic acute renal failure Heleen M Oudemans-van Straaten Critical Care 2008, 12:126 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Pulmonary artery occlusion pressure estimation by transesophageal echocardiography: is simpler better? Gorazd Voga Critical Care 2008, 12:127 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Tracheostomy decannulation: marathons and finish lines John E Heffner Critical Care 2008, 12:128 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Myocardial infarction on the ICU: can we do better? Ian Webb, James Coutts Critical Care 2008, 12:129 (3 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary The pursuit of a high central venous oxygen saturation in sepsis: growing concerns Rinaldo Bellomo, Michael C Reade, Stephen J Warrillow Critical Care 2008, 12:130 (7 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Delirium assessment in the intensive care unit: patient population matters Margaret A Pisani Critical Care 2008, 12:131 (7 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Vasopressin in vasodilatory shock: is the heart in danger? Balázs Hauser, Pierre Asfar, Enrico Calzia, Régent Laporte, Michael Georgieff, Peter Radermacher Critical Care 2008, 12:132 (10 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Patient-level glucose reporting: averages, episodes, or something in between? Susan S Braithwaite Critical Care 2008, 12:133 (10 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Competing risks models and time-dependent covariates Adrian Barnett, Nick Graves Critical Care 2008, 12:134 (11 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution? Ariel Jaitovich, Jacob Sznajder Critical Care 2008, 12:135 (15 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Noninvasive mechanical ventilation during the weaning process: facilitative, curative, or preventive? Massimo Antonelli, Giuseppe Bello Critical Care 2008, 12:136 (21 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Pharmacotherapeutic friendly fire in the intensive care unit: high stakes seeking high calibre Christopher S Parshuram Critical Care 2008, 12:137 (22 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Hypothermia and cardiac arrest: the promise of intra-arrest cooling Roger A Band, Benjamin S Abella Critical Care 2008, 12:138 (22 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Protein C as a surrogate end-point for clinical trials of sepsis Kathleen D Liu, Michael A Matthay Critical Care 2008, 12:139 (24 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Steroids in sepsis: another swing of the pendulum in our clinical trials Jean-Louis Vincent Critical Care 2008, 12:141 (29 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Editor-in-chief Jean-Louis Vincent explains that the search for interventions in sepsis needs to be reassessed in light of disappointing results from clinical trials, including the Corticus study.
	Commentary Pain may be inevitable; inadequate management is not Yoanna Skrobik Critical Care 2008, 12:142 (29 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary The evidence for small-volume resuscitation with hyperoncotic albumin in critical illness John A Myburgh Critical Care 2008, 12:143 (30 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary The inflammation–coagulation axis as an important intermediate pathway in acute lung injury Marcel Levi, Marcus Schultz Critical Care 2008, 12:144 (30 April 2008) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Clinical review: Critical care transport and austere critical care David H Rice, George Kotti, William Beninati Critical Care 2008, 12:207 (5 March 2008) Abstract \| Full text \| PDF \| PubMed
	Review Clinical review: Medication errors in critical care Eric Moyen, Eric Camiré, Henry Stelfox Critical Care 2008, 12:208 (12 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Clinical review: Airway hygiene in the intensive care unit Sanja Jelic, Jennifer A Cunningham, Phillip Factor Critical Care 2008, 12:209 (31 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: The evaluation of complex interventions in critical care Anthony Delaney, Derek C Angus, Rinaldo Bellomo, Peter Cameron, D James Cooper, Simon Finfer, David A Harrison, David T Huang, John A Myburgh, Sandra L Peake, Michael C Reade, Steve AR Webb, Donald M Yealy, the Australian Resuscitation in Sepsis Evaluation (ARISE), Protocolized Care for Early Septic Shock (ProCESS) and Protocolised Management In Sepsis (ProMISe) investigators Critical Care 2008, 12:210 (14 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Pro/con debate: Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patients? Tobias M Merz, Simon Finfer Critical Care 2008, 12:212 (25 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Journal club critique Rethinking bystander CPR for out-of-hospital cardiac arrest Scott A Crane, Clifton W Callaway, Eric B Milbrandt, David T Huang Critical Care 2008, 12:302 (12 March 2008) Full text \| PDF \| PubMed
	Research
	Research Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors Deborah Cook, James Douketis, Maureen Meade, Gordon Guyatt, Nicole Zytaruk, John Granton, Yoanna Skrobik, Martin Albert, Robert Fowler, Paul Hebert, Guiseppe Pagliarello, Jan Friedrich, Andreas Freitag, Tim Karachi, Christian Rabbat, Diane Heels-Ansdell, William Geerts, Mark Crowther, the Canadian Critical Care Trials Group Critical Care 2008, 12:R32 (3 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands Paul A van Beest, Jorrit J Hofstra, Marcus J Schultz, E C Boerma, Peter E Spronk, Michael A Kuiper Critical Care 2008, 12:R33 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials Matthias Jacob, Daniel Chappell, Peter Conzen, Mahlon M Wilkes, Bernhard F Becker, Markus Rehm Critical Care 2008, 12:R34 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock Anand Kumar, Elizabeth Schupp, Eugene Bunnell, Amjad Ali, Barry Milcarek, Joseph E Parrillo Critical Care 2008, 12:R35 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings Wendy Lim, Paula Holinski, PJ Devereaux, Andrea Tkaczyk, Ellen McDonald, France Clarke, Ismael Qushmaq, Irene Terrenato, Holger Schunemann, Mark Crowther, Deborah Cook Critical Care 2008, 12:R36 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Ability of pleth variability index to detect hemodynamic changes induced by passive leg raising in spontaneously breathing volunteers Geoffray Keller, Emmanuel Cassar, Olivier Desebbe, Jean-Jacques Lehot, Maxime Cannesson Critical Care 2008, 12:R37 (6 March 2008) Abstract \| Full text \| PDF \| PubMed
	Research The histopathology of septic acute kidney injury: a systematic review Christoph Langenberg, Sean M Bagshaw, Clive N May, Rinaldo Bellomo Critical Care 2008, 12:R38 (6 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The association of acute tubular necrosis with septic acute kidney injury was not supported by a systematic review of the literature, which also questioned the histopathological link between the two.
	Research Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats Virginia Chamorro-Marín, Manuel García-Delgado, Angel Touma-Fernández, Eduardo Aguilar-Alonso, Enrique Fernández-Mondejar Critical Care 2008, 12:R39 (10 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intratracheal dopamine administration improves pulmonary edema clearance and is associated with significantly higher survival in a randomized, controlled rat model of ventilator-induced lung injury.
	Research Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study Konstantinos Stroumpoulis, Theodoros Xanthos, Georgios Rokas, Vassiliki Kitsou, Dimitrios Papadimitriou, Ioannis Serpetinis, Despina Perrea, Lila Papadimitriou, Evangelia Kouskouni Critical Care 2008, 12:R40 (14 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vasopressin, when administered in combination with epinephrine during cardiopulmonary resuscitation, drastically improves the hemodynamic parameters necessary for return of spontaneous circulation, shows a randomized study of 22 piglets.
	Research Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury Dana McClintock, Hanjing Zhuo, Nancy Wickersham, Michael A Matthay, Lorraine B Ware Critical Care 2008, 12:R41 (21 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Circulating plasma factors induce tubular and glomerular alterations in septic burns patients Filippo Mariano, Vincenzo Cantaluppi, Maurizio Stella, Giuseppe Romanazzi, Barbara Assenzio, Monica Cairo, Luigi Biancone, Giorgio Triolo, V Marco Ranieri, Giovanni Camussi Critical Care 2008, 12:R42 (25 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Danaparoid sodium inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in rats Satoshi Hagiwara, Hideo Iwasaka, Seigo Hidaka, Sohei Hishiyama, Takayuki Noguchi Critical Care 2008, 12:R43 (2 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models Martin Wolkewitz, Ralf Vonberg, Hajo Grundmann, Jan Beyersmann, Petra Gastmeier, Sina Bärwolff, Christine Geffers, Michael Behnke, Henning Rüden, Martin Schumacher Critical Care 2008, 12:R44 (2 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) Andrew F Shorr, David R Nelson, Duncan LA Wyncoll, Konrad Reinhart, Frank Brunkhorst, George Vail, Jonathan Janes Critical Care 2008, 12:R45 (4 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology \| Editor’s summary Protein C was the only variable consistently correlated with both DrotAA treatment effect and survival based on systematic analyses of 6 biomarkers and 5 organ dysfunctions measured in severe sepsis clinical trials.
	Research Introduction of Medical Emergency Teams in Australia and New Zealand: a multi-centre study Daryl Jones, Carol George, Graeme K Hart, Rinaldo Bellomo, Jacqueline Martin Critical Care 2008, 12:R46 (7 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Early acute kidney injury and sepsis: a multicentre evaluation Sean M Bagshaw, Carol George, Rinaldo Bellomo, the ANZICS Database Management Committee Critical Care 2008, 12:R47 (10 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Patients with septic acute kidney injury (AKI) have a higher burden of illness than patients with non-septic AKI, an evaluation of more than 120,000 intensive care unit admissions has found.
	Research An intensivist-led tracheostomy review team is associated with shorter decannulation time and length of stay: a prospective cohort study Antony E Tobin, John D Santamaria Critical Care 2008, 12:R48 (11 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change J Geoffrey Chase, Geoffrey Shaw, Aaron Le Compte, Timothy Lonergan, Michael Willacy, Xing-Wei Wong, Jessica Lin, Thomas Lotz, Dominic Lee, Christopher Hann Critical Care 2008, 12:R49 (16 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Respiratory effects of different recruitment maneuvers in acute respiratory distress syndrome Jean-Michel Constantin, Samir Jaber, Emmanuel Futier, Sophie Cayot-Constantin, Myriam Verny-Pic, Boris Jung, Anne Bailly, Renaud Guerin, Jean-Etienne Bazin Critical Care 2008, 12:R50 (16 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Pulmonary mechanics-based recruitment maneuvers (eSigh) increased both recruited volume and oxygenation in patients with acute respiratory distress syndrome, whereas continuous pulmonary airway pressure only increased oxygenation.
	Research Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation: a randomized clinical trial Cristiane E Trevisan, Silvia R Vieira, the Research Group in Mechanical Ventilation Weaning Critical Care 2008, 12:R51 (17 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial Richard S Bourne, Gary H Mills, Cosetta Minelli Critical Care 2008, 12:R52 (18 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modelling Lisbet Niklason, Johannes Eckerström, Björn Jonson Critical Care 2008, 12:R53 (18 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective Judith Martini, Pedro Cabrales, Ananda K, Seetharama A Acharya, Marcos Intaglietta, Amy G Tsai Critical Care 2008, 12:R54 (18 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	Research Effect of a heated humidifier during continuous positive airway pressure delivered by a helmet Davide Chiumello, Monica Chierichetti, Federica Tallarini, Paola Cozzi, Massimo Cressoni, Federico Polli, Riccardo Colombo, Antonio Castelli, Luciano Gattinoni Critical Care 2008, 12:R55 (21 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Diagnosis of ventilator-associated pneumonia: a systematic review of the literature Alvaro Rea-Neto, Nazah Youssef, Fabio Tuche, Frank Brunkhorst, V Marco Ranieri, Konrad Reinhart, Yasser Sakr Critical Care 2008, 12:R56 (21 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Development of a triage protocol for patients presenting with gastrointestinal hemorrhage: a prospective cohort study Aneesa M Das, Namita Sood, Katherine Hodgin, Lydia Chang, Shannon S Carson Critical Care 2008, 12:R57 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Drotrecogin alfa (activated): real-life use and outcomes for the UK Kathryn M Rowan, Catherine A Welch, Emma North, David A Harrison Critical Care 2008, 12:R58 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units Khalid Abidi, Ibtissam Khoudri, Jihane Belayachi, Naoufel Madani, Aicha Zekraoui, Amine Zeggwagh, Redouane Abouqal Critical Care 2008, 12:R59 (24 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Anemia, transfusions and hospital outcomes among critically ill patients on prolonged acute mechanical ventilation: a retrospective cohort study Marya D Zilberberg, Lee S Stern, Daniel P Wiederkehr, John J Doyle, Andrew F Shorr Critical Care 2008, 12:R60 (28 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial Guomin Xiao, Jing Wei, Weiqi Yan, Weimin Wang, Zhenhui Lu Critical Care 2008, 12:R61 (30 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Correspondence
	Letter Discriminating invasive fungal infection from colonization Stijn Blot, Koenraad Vandewoude, Dirk Vogelaers Critical Care 2008, 12:412 (3 April 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Prehospital therapeutic hypothermia in cardiac arrest: will there ever be evidence? Joerg C Schefold, Christian Storm, Dietrich Hasper Critical Care 2008, 12:413 (9 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Saccharomyces boulardii fungaemia in an intensive care unit patient treated with caspofungin Nikolaos Lolis, Dimitrios Veldekis, Hellen Moraitou, Sofia Kanavaki, Aristea Velegraki, Charis Triandafyllidis, Chronis Tasioudis, Angellos Pefanis, Ioannis Pneumatikos Critical Care 2008, 12:414 (9 April 2008) Abstract \| Full text \| PDF \| PubMed \| 1 comment
	Letter Vasopressor stays vasopressor and inotrope stays inotrope! Günter Luckner, Walter R Hasibeder, Martin W Dünser Critical Care 2008, 12:415 (14 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter The nature of unmeasured anions in critically ill patients Miriam AM Moviat, Peter Pickkers, Wim Ruitenbeek, Johannes G van der Hoeven Critical Care 2008, 12:416 (22 April 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Chaotic nature of sepsis and multiple organ failure cannot be explained by linear statistical methods Sarah Saliba, Yusuf Kilic, Selman Uranues Critical Care 2008, 12:417 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Withholding and withdrawing life-sustaining treatment: the necessity of discrepancies in ethical reasoning Frédéric Pochard, Nancy Kentish-Barnes, Elie Azoulay Critical Care 2008, 12:418 (29 April 2008) Abstract \| Full text \| PDF \| PubMed

	Volume 12 Issue 2
	Comment
	Editorial Relaunching the Pro–Con section at Critical Care Thomas E Stewart Critical Care 2008, 12:140 (25 April 2008) Abstract \| Full text \| PDF
	Commentary Copeptin: a new and promising diagnostic and prognostic marker Mira Katan, Beat Müller, Mirjam Christ-Crain Critical Care 2008, 12:117 (6 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Cardiovascular and metabolic responses to catecholamine and sepsis prognosis: a ubiquitous phenomenon? Solène Collin, Nacira Sennoun, Bruno Levy Critical Care 2008, 12:118 (17 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Towards goal-directed therapy of hepatorenal syndrome: we have the tools but we need the trials Rajeshwar P Mookerjee, Rajiv Jalan Critical Care 2008, 12:119 (19 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Recently published papers: Sepsis – guidelines, treatment and novel approaches Navneet Kalsi, Lui G Forni Critical Care 2008, 12:120 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary KL-6 in acute lung injury: will it leave its mark? Murali Shyamsundar, Danny F McAuley Critical Care 2008, 12:121 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Lost in translation? The pursuit of lung-protective ventilation Andrew T Jones Critical Care 2008, 12:122 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Optimal vasopressor drug therapy during resuscitation Joseph P Ornato Critical Care 2008, 12:123 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Insulin, intracerebral glucose and bedside biochemical monitoring utilizing microdialysis Carl-Henrik Nordström Critical Care 2008, 12:124 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Knowing who would respond to a recruitment maneuver before actually doing it – this might be a way to go Ralf Kuhlen Critical Care 2008, 12:125 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Circulating pro-apoptotic mediators in burn septic acute renal failure Heleen M Oudemans-van Straaten Critical Care 2008, 12:126 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Pulmonary artery occlusion pressure estimation by transesophageal echocardiography: is simpler better? Gorazd Voga Critical Care 2008, 12:127 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Tracheostomy decannulation: marathons and finish lines John E Heffner Critical Care 2008, 12:128 (31 March 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Myocardial infarction on the ICU: can we do better? Ian Webb, James Coutts Critical Care 2008, 12:129 (3 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary The pursuit of a high central venous oxygen saturation in sepsis: growing concerns Rinaldo Bellomo, Michael C Reade, Stephen J Warrillow Critical Care 2008, 12:130 (7 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Delirium assessment in the intensive care unit: patient population matters Margaret A Pisani Critical Care 2008, 12:131 (7 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Vasopressin in vasodilatory shock: is the heart in danger? Balázs Hauser, Pierre Asfar, Enrico Calzia, Régent Laporte, Michael Georgieff, Peter Radermacher Critical Care 2008, 12:132 (10 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Patient-level glucose reporting: averages, episodes, or something in between? Susan S Braithwaite Critical Care 2008, 12:133 (10 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Competing risks models and time-dependent covariates Adrian Barnett, Nick Graves Critical Care 2008, 12:134 (11 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution? Ariel Jaitovich, Jacob Sznajder Critical Care 2008, 12:135 (15 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Noninvasive mechanical ventilation during the weaning process: facilitative, curative, or preventive? Massimo Antonelli, Giuseppe Bello Critical Care 2008, 12:136 (21 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Pharmacotherapeutic friendly fire in the intensive care unit: high stakes seeking high calibre Christopher S Parshuram Critical Care 2008, 12:137 (22 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Hypothermia and cardiac arrest: the promise of intra-arrest cooling Roger A Band, Benjamin S Abella Critical Care 2008, 12:138 (22 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Protein C as a surrogate end-point for clinical trials of sepsis Kathleen D Liu, Michael A Matthay Critical Care 2008, 12:139 (24 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary Steroids in sepsis: another swing of the pendulum in our clinical trials Jean-Louis Vincent Critical Care 2008, 12:141 (29 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Editor-in-chief Jean-Louis Vincent explains that the search for interventions in sepsis needs to be reassessed in light of disappointing results from clinical trials, including the Corticus study.
	Commentary Pain may be inevitable; inadequate management is not Yoanna Skrobik Critical Care 2008, 12:142 (29 April 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary The evidence for small-volume resuscitation with hyperoncotic albumin in critical illness John A Myburgh Critical Care 2008, 12:143 (30 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Commentary The inflammation–coagulation axis as an important intermediate pathway in acute lung injury Marcel Levi, Marcus Schultz Critical Care 2008, 12:144 (30 April 2008) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Clinical review: Critical care transport and austere critical care David H Rice, George Kotti, William Beninati Critical Care 2008, 12:207 (5 March 2008) Abstract \| Full text \| PDF \| PubMed
	Review Clinical review: Medication errors in critical care Eric Moyen, Eric Camiré, Henry Stelfox Critical Care 2008, 12:208 (12 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Clinical review: Airway hygiene in the intensive care unit Sanja Jelic, Jennifer A Cunningham, Phillip Factor Critical Care 2008, 12:209 (31 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Bench-to-bedside review: The evaluation of complex interventions in critical care Anthony Delaney, Derek C Angus, Rinaldo Bellomo, Peter Cameron, D James Cooper, Simon Finfer, David A Harrison, David T Huang, John A Myburgh, Sandra L Peake, Michael C Reade, Steve AR Webb, Donald M Yealy, the Australian Resuscitation in Sepsis Evaluation (ARISE), Protocolized Care for Early Septic Shock (ProCESS) and Protocolised Management In Sepsis (ProMISe) investigators Critical Care 2008, 12:210 (14 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Pro/con debate: Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patients? Tobias M Merz, Simon Finfer Critical Care 2008, 12:212 (25 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Journal club critique Rethinking bystander CPR for out-of-hospital cardiac arrest Scott A Crane, Clifton W Callaway, Eric B Milbrandt, David T Huang Critical Care 2008, 12:302 (12 March 2008) Full text \| PDF \| PubMed
	Research
	Research Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors Deborah Cook, James Douketis, Maureen Meade, Gordon Guyatt, Nicole Zytaruk, John Granton, Yoanna Skrobik, Martin Albert, Robert Fowler, Paul Hebert, Guiseppe Pagliarello, Jan Friedrich, Andreas Freitag, Tim Karachi, Christian Rabbat, Diane Heels-Ansdell, William Geerts, Mark Crowther, the Canadian Critical Care Trials Group Critical Care 2008, 12:R32 (3 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands Paul A van Beest, Jorrit J Hofstra, Marcus J Schultz, E C Boerma, Peter E Spronk, Michael A Kuiper Critical Care 2008, 12:R33 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials Matthias Jacob, Daniel Chappell, Peter Conzen, Mahlon M Wilkes, Bernhard F Becker, Markus Rehm Critical Care 2008, 12:R34 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock Anand Kumar, Elizabeth Schupp, Eugene Bunnell, Amjad Ali, Barry Milcarek, Joseph E Parrillo Critical Care 2008, 12:R35 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings Wendy Lim, Paula Holinski, PJ Devereaux, Andrea Tkaczyk, Ellen McDonald, France Clarke, Ismael Qushmaq, Irene Terrenato, Holger Schunemann, Mark Crowther, Deborah Cook Critical Care 2008, 12:R36 (4 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Ability of pleth variability index to detect hemodynamic changes induced by passive leg raising in spontaneously breathing volunteers Geoffray Keller, Emmanuel Cassar, Olivier Desebbe, Jean-Jacques Lehot, Maxime Cannesson Critical Care 2008, 12:R37 (6 March 2008) Abstract \| Full text \| PDF \| PubMed
	Research The histopathology of septic acute kidney injury: a systematic review Christoph Langenberg, Sean M Bagshaw, Clive N May, Rinaldo Bellomo Critical Care 2008, 12:R38 (6 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The association of acute tubular necrosis with septic acute kidney injury was not supported by a systematic review of the literature, which also questioned the histopathological link between the two.
	Research Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats Virginia Chamorro-Marín, Manuel García-Delgado, Angel Touma-Fernández, Eduardo Aguilar-Alonso, Enrique Fernández-Mondejar Critical Care 2008, 12:R39 (10 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intratracheal dopamine administration improves pulmonary edema clearance and is associated with significantly higher survival in a randomized, controlled rat model of ventilator-induced lung injury.
	Research Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study Konstantinos Stroumpoulis, Theodoros Xanthos, Georgios Rokas, Vassiliki Kitsou, Dimitrios Papadimitriou, Ioannis Serpetinis, Despina Perrea, Lila Papadimitriou, Evangelia Kouskouni Critical Care 2008, 12:R40 (14 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vasopressin, when administered in combination with epinephrine during cardiopulmonary resuscitation, drastically improves the hemodynamic parameters necessary for return of spontaneous circulation, shows a randomized study of 22 piglets.
	Research Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury Dana McClintock, Hanjing Zhuo, Nancy Wickersham, Michael A Matthay, Lorraine B Ware Critical Care 2008, 12:R41 (21 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Circulating plasma factors induce tubular and glomerular alterations in septic burns patients Filippo Mariano, Vincenzo Cantaluppi, Maurizio Stella, Giuseppe Romanazzi, Barbara Assenzio, Monica Cairo, Luigi Biancone, Giorgio Triolo, V Marco Ranieri, Giovanni Camussi Critical Care 2008, 12:R42 (25 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Danaparoid sodium inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in rats Satoshi Hagiwara, Hideo Iwasaka, Seigo Hidaka, Sohei Hishiyama, Takayuki Noguchi Critical Care 2008, 12:R43 (2 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models Martin Wolkewitz, Ralf Vonberg, Hajo Grundmann, Jan Beyersmann, Petra Gastmeier, Sina Bärwolff, Christine Geffers, Michael Behnke, Henning Rüden, Martin Schumacher Critical Care 2008, 12:R44 (2 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) Andrew F Shorr, David R Nelson, Duncan LA Wyncoll, Konrad Reinhart, Frank Brunkhorst, George Vail, Jonathan Janes Critical Care 2008, 12:R45 (4 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology \| Editor’s summary Protein C was the only variable consistently correlated with both DrotAA treatment effect and survival based on systematic analyses of 6 biomarkers and 5 organ dysfunctions measured in severe sepsis clinical trials.
	Research Introduction of Medical Emergency Teams in Australia and New Zealand: a multi-centre study Daryl Jones, Carol George, Graeme K Hart, Rinaldo Bellomo, Jacqueline Martin Critical Care 2008, 12:R46 (7 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Early acute kidney injury and sepsis: a multicentre evaluation Sean M Bagshaw, Carol George, Rinaldo Bellomo, the ANZICS Database Management Committee Critical Care 2008, 12:R47 (10 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Patients with septic acute kidney injury (AKI) have a higher burden of illness than patients with non-septic AKI, an evaluation of more than 120,000 intensive care unit admissions has found.
	Research An intensivist-led tracheostomy review team is associated with shorter decannulation time and length of stay: a prospective cohort study Antony E Tobin, John D Santamaria Critical Care 2008, 12:R48 (11 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change J Geoffrey Chase, Geoffrey Shaw, Aaron Le Compte, Timothy Lonergan, Michael Willacy, Xing-Wei Wong, Jessica Lin, Thomas Lotz, Dominic Lee, Christopher Hann Critical Care 2008, 12:R49 (16 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Respiratory effects of different recruitment maneuvers in acute respiratory distress syndrome Jean-Michel Constantin, Samir Jaber, Emmanuel Futier, Sophie Cayot-Constantin, Myriam Verny-Pic, Boris Jung, Anne Bailly, Renaud Guerin, Jean-Etienne Bazin Critical Care 2008, 12:R50 (16 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Pulmonary mechanics-based recruitment maneuvers (eSigh) increased both recruited volume and oxygenation in patients with acute respiratory distress syndrome, whereas continuous pulmonary airway pressure only increased oxygenation.
	Research Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation: a randomized clinical trial Cristiane E Trevisan, Silvia R Vieira, the Research Group in Mechanical Ventilation Weaning Critical Care 2008, 12:R51 (17 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial Richard S Bourne, Gary H Mills, Cosetta Minelli Critical Care 2008, 12:R52 (18 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modelling Lisbet Niklason, Johannes Eckerström, Björn Jonson Critical Care 2008, 12:R53 (18 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective Judith Martini, Pedro Cabrales, Ananda K, Seetharama A Acharya, Marcos Intaglietta, Amy G Tsai Critical Care 2008, 12:R54 (18 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	Research Effect of a heated humidifier during continuous positive airway pressure delivered by a helmet Davide Chiumello, Monica Chierichetti, Federica Tallarini, Paola Cozzi, Massimo Cressoni, Federico Polli, Riccardo Colombo, Antonio Castelli, Luciano Gattinoni Critical Care 2008, 12:R55 (21 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Diagnosis of ventilator-associated pneumonia: a systematic review of the literature Alvaro Rea-Neto, Nazah Youssef, Fabio Tuche, Frank Brunkhorst, V Marco Ranieri, Konrad Reinhart, Yasser Sakr Critical Care 2008, 12:R56 (21 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Development of a triage protocol for patients presenting with gastrointestinal hemorrhage: a prospective cohort study Aneesa M Das, Namita Sood, Katherine Hodgin, Lydia Chang, Shannon S Carson Critical Care 2008, 12:R57 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Drotrecogin alfa (activated): real-life use and outcomes for the UK Kathryn M Rowan, Catherine A Welch, Emma North, David A Harrison Critical Care 2008, 12:R58 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units Khalid Abidi, Ibtissam Khoudri, Jihane Belayachi, Naoufel Madani, Aicha Zekraoui, Amine Zeggwagh, Redouane Abouqal Critical Care 2008, 12:R59 (24 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Research Anemia, transfusions and hospital outcomes among critically ill patients on prolonged acute mechanical ventilation: a retrospective cohort study Marya D Zilberberg, Lee S Stern, Daniel P Wiederkehr, John J Doyle, Andrew F Shorr Critical Care 2008, 12:R60 (28 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial Guomin Xiao, Jing Wei, Weiqi Yan, Weimin Wang, Zhenhui Lu Critical Care 2008, 12:R61 (30 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology
	Correspondence
	Letter Discriminating invasive fungal infection from colonization Stijn Blot, Koenraad Vandewoude, Dirk Vogelaers Critical Care 2008, 12:412 (3 April 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Prehospital therapeutic hypothermia in cardiac arrest: will there ever be evidence? Joerg C Schefold, Christian Storm, Dietrich Hasper Critical Care 2008, 12:413 (9 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Saccharomyces boulardii fungaemia in an intensive care unit patient treated with caspofungin Nikolaos Lolis, Dimitrios Veldekis, Hellen Moraitou, Sofia Kanavaki, Aristea Velegraki, Charis Triandafyllidis, Chronis Tasioudis, Angellos Pefanis, Ioannis Pneumatikos Critical Care 2008, 12:414 (9 April 2008) Abstract \| Full text \| PDF \| PubMed \| 1 comment
	Letter Vasopressor stays vasopressor and inotrope stays inotrope! Günter Luckner, Walter R Hasibeder, Martin W Dünser Critical Care 2008, 12:415 (14 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter The nature of unmeasured anions in critically ill patients Miriam AM Moviat, Peter Pickkers, Wim Ruitenbeek, Johannes G van der Hoeven Critical Care 2008, 12:416 (22 April 2008) Abstract \| Full text \| PDF \| PubMed
	Letter Chaotic nature of sepsis and multiple organ failure cannot be explained by linear statistical methods Sarah Saliba, Yusuf Kilic, Selman Uranues Critical Care 2008, 12:417 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Letter Withholding and withdrawing life-sustaining treatment: the necessity of discrepancies in ethical reasoning Frédéric Pochard, Nancy Kentish-Barnes, Elie Azoulay Critical Care 2008, 12:418 (29 April 2008) Abstract \| Full text \| PDF \| PubMed

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