Christoph Langenberg1,2
, Sean M Bagshaw1,3
, Clive N May1
and Rinaldo Bellomo1,4 
1Department of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Melbourne, Victoria 3084, Australia
2Howard Florey Institute, University of Melbourne, Grattan St, Parkville, Melbourne, Victoria, Australia
3Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 112 Street NW, Edmonton, Alberta, BBT6G2B7, Canada
4Department of Medicine, Melbourne University, Grattan St. Parkville, Victoria 3052, Melbourne, Australia