|
Human studies |
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| Study |
Cause |
Acute kidney injury definition |
Method |
Cases of AKI/number of patients (%) |
Acute tubular necrosis (%) |
|
|
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| Hotchkiss and colleagues [10] |
Sepsis/septic shock |
Serum creatinine >2 mg/dl and urine output <20 ml/kg/hour × 6 hours |
Postmortem |
12/20 (60) |
1 (5) |
| Sato and colleagues [13] |
Sepsis |
Not available |
Postmortem |
6/6 (100) |
1 (17) |
| Mustonen and colleagues [9] |
Sepsis/shock/hypovolemia |
Not available |
Biopsy |
57/57 (100) |
4 (7) |
| Rosenberg and colleagues [12] |
Sepsis |
Serum creatinine >3.5 mg/dl and urine/plasma osmolality >1 |
Biopsy |
1/1 (100) |
0 (0) |
| Zappacosta and Ashby [14] |
Sepsis |
Not available |
Biopsy |
1/1 (100) |
0 (0) |
| Diaz de Leon and colleagues [11] |
Severe sepsis |
Serum creatinine, urine output, urine/plasma osmolality (not specified) |
Biopsy |
107/332 (32) |
20 (50)a |
|
aRenal biopsy was only performed in 40 patients (37% of the acute kidney injury (AKI) cohort, 12% of the total cohort). | |||||
Langenberg et al. Critical Care 2008 12:R38 doi:10.1186/cc6823 |
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