Figure 2.

Biomarkers of disordered coagulation and fibrinolysis in acute lung injury and acute respiratory distress syndrome. Comparison of plasma levels of biomarkers of disordered coagulation and fibrinolysis in 50 patients with acute lung injury and acute respiratory distress syndrome ventilated with low-tidal-volume ventilation. (a) Plasma levels of protein C were significantly lower in nonsurvivors compared with survivors. (b) Plasma levels of thrombomodulin were significantly higher in nonsurvivors compared with survivors. (c) Plasma levels of plasminogen activator inhibitor 1 (PAI-1) were significantly higher in nonsurvivors compared with survivors. Data shown as boxplots: horizontal line, median; box, 25th to 75th percentiles; error bars, 10th to 90th percentiles. *P = 0.0003, **P = 0.005 and ^§P = 0.01 compared with survivors, Mann–Whitney U test.