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Summary of acute physiology and laboratory parameters by sepsis and AKI |
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| None (n = 57,392) |
Sepsis, no AKI (n = 19,336) |
Nonseptic AKI (n = 29,356) |
Septic AKI (n = 14,039) |
P |
|
|
|
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| APACHE II score (mean [SD]) |
14.4 (6.4) |
15.4 (7.0) |
20.0 (7.9) |
22.3 (8.1) |
<0.0001 |
| GCS score (median [IQR]) |
15 (14–15) |
15 (13–15) |
15 (13–15) |
15 (12–15) |
0.001 |
| Mean arterial pressure (mmHg; mean [SD]) |
84.3 (26.9) |
86.5 (27.7) |
81.3 (28.2) |
77.5 (28.3) |
<0.0001 |
| Heart rate (beats/minute; mean [SD]) |
91 (31) |
96 (32) |
96 (33) |
104 (35) |
<0.0001 |
| Respiratory rate (breaths/minute; mean [SD]) |
18 (10) |
20 (11) |
20 (10) |
23 (11) |
<0.0001 |
| PaO2/FiO2 ratio (mean [SD]) |
287 (154) |
262 (145) |
260 (153) |
230 (140) |
<0.0001 |
| PaCO2 (mmHg; mean [SD]) |
42.7 (12.4) |
42.5 (13.1) |
43.2 (14.5) |
42.0 (14.5) |
<0.0001 |
| Temperature (°C; mean [SD]) |
36.7 (1.5) |
36.8 (1.6) |
36.6 (1.6) |
36.9 (1.7) |
<0.0001 |
| Mechanical ventilation (%) |
53.3 |
49.5 |
52.6 |
49.2 |
<0.0001 |
| pH (mean [SD]) |
7.35 (0.1) |
7.35 (0.1) |
7.30 (0.1) |
7.29 (0.1) |
<0.0001 |
| Bilirubin (mmol/l; median [IQR]) |
12 (6–18) |
12 (6–18) |
13 (6–19) |
14 (7–21) |
0.0001 |
| Albumin (g/l; mean [SD]) |
28.2 (7.4) |
27.8 (7.6) |
26.2 (7.6) |
25.1 (7.4) |
<0.0001 |
| Haematocrit (%; median [IQR]) |
0.33 (0.28–0.39) |
0.34 (0.28–0.39) |
0.31 (0.27–0.39) |
0.32 (0.27–0.38) |
0.0001 |
| White cell count (× 109 cells/ml; mean [SD]) |
13.4 (9.7) |
14.2 (13.8) |
15.0 (11.5) |
16.8 (14.7) |
<0.0001 |
| Potassium (mmol/l; mean [SD]) |
4.2 (0.7) |
4.1 (0.7) |
4.5 (1.0) |
4.4 (1.0) |
<0.0001 |
| Creatinine (μmol/l; median [IQR]) |
76 (60–90) |
73 (57–90) |
141 (113–200) |
165 (124–254) |
0.0001 |
| Urea (mmol/l; median [IQR]) |
5.3 (4–7) |
5.6 (4–7.8) |
10.4 (7.3–16.1) |
13.2 (8.9–19.8) |
0.0001 |
| Urine output (l/24 hours; median [IQR]) |
2.12 (1.54–2.97) |
2.05 (1.50–2.98) |
1.40 (0.68–2.28) |
1.39 (0.66–2.30) |
0.0001 |
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APACHE, Acute Physiology and Chronic Health Evaluation; FiO2, fraction of inspired oxygen; GCS, Glasgow Coma Scale; IQR, interquartile range; PaCO2, arterial oxygen tension; PaO2, arterial oxygen tension; SD, standard deviation. | |||||
Bagshaw et al. Critical Care 2008 12:R47 doi:10.1186/cc6863 |
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