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Studies comparing quantitative cultures to clinical diagnosis |
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| First author |
Sample |
Dx tests |
Gold standard |
Results |
|
|
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| Camargo, 2004, ** [59] |
Mixed ICU, 106 pts |
TA (105 and 106) & TA (qualit) |
Clinical (ad hoc) |
• TA (106): sens = 26%, spec = 78%, PPV = 20%, NPV = 83% • TA (105): sens = 65%, spec = 48%, PPV = 21%, NPV = 87% • TA (qualit): sens = 81%, spec = 23%, PPV = 18%, NPV = 86% |
| Mentec, 2004, ** [60] |
Mixed ICU, 63 pts |
TA (105), bPTC (103), PTC (103), BAL (104) |
Clinical + Rx (ad hoc) |
• For quantitative cultures: TA: sens = 82%, spec = 67%, ROC = 0,78; bPTC: sens = 62%, spec = 94%, ROC = 0,83; PTC: sens = 71%, spec = 94%, ROC = 0,85; BAL: sens = 94%, spec = 100%, ROC = 0.98 • For Gram stain: TA: sens = 94%, spec = 50%; bPTC: sens = 56%, spec = 94%; PTC sens = 65%, spec = 83%; BAL sens = 100%, spec = 94% |
| Woske, 2001, ** [61] |
Surgical ICU, 103 pts, consecutive |
BAL (104) & PSB (103) & TA (105 and 106) |
CPIS ≥6 |
• BAL: sens = 90%. • PSB: sens = 83%. • TA (105): sens = 90%. • TA (106): sens = 50%. |
| Meduri, 1992, ** [84] |
Mixed ICU, 25 pts |
pBAL (104) & PSB |
Clinical |
• pBAL: Spec = 100%, NPV = 100% |
| Salata, 1987, ** [85] |
Mixed ICU, 51 pts |
TA |
Clinical |
• TA: higher Gram stain grading for neutrophils: p < 0.05 • TA: higher bacterial colony count: p < 0.05 |
| Castro, 1991, ** [86] |
Mixed ICU, 103 pts |
PSB (103) |
Clinical |
• PSB: sens = 84%, spec = 67% |
|
ICU = intensive care unit; TA = tracheal aspiration; qualit. = qualitative; BAL = bronchoalveolar lavage; sens = sensitivity; spec = specificity; bPTC = blinded protected telescoping catheter; PTC = protected (plugged) telescoping catheter; PPV = positive predictive value; NPV = negative predictive value; PSB = protected specimen brush; CPIS = clinical pulmonary infection score; pBAL = protected bronchoalveolar lavage; **consecutive | ||||
Rea-Neto et al. Critical Care 2008 12:R56 doi:10.1186/cc6877 |
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