Table 7 |
||||
|
Studies evaluating the value of biomarkers in diagnosing VAP |
||||
|
First author |
Sample |
Dx Tests |
Gold standard |
Results |
|
|
||||
|
Povoa, 2005, # [73] |
Mixed ICU, 112 pts |
CRP |
Johanson |
CRP (>9.6 mg/dl): sens = 87%, spec = 88%, AUC = 0.92. |
|
Gibot, 2004, ** [75] |
Mixed ICU, 148 pts |
sTREM-1 in mini-BAL |
Mini-BAL (103) Clinical (ad hoc) |
Sens = 98%, spec = 90%. |
|
Duflo, 2002, ** [71] |
Mixed ICU, 96 pts |
PCT serum & alveolar |
Mini-BAL (103) |
Serum PCT (≥3.9 ng/ml): sens = 41%, spec = 100%, AUC = 0787. Alveolar PCT: not useful. |
|
Oppert, 2002, ** [72] |
Mixed ICU, 28 pts |
PCT and PCR |
Clinical (ad hoc) |
Serum PCT (>1 ng/ml): sens = 100%, spec = 75%. |
|
El-Ebiary, 1995, *, ** [69] |
Mixed ICU, 78 pts |
Elastin fibre |
Clinical (ad hoc) |
EF: sens = 32%, spec = 72%. |
|
Determann, 2005, ** [76] |
Mixed ICU, 28 pts |
sTREM-1 |
Clinical & NBLF |
Sens = 75%, spec = 84%. |
|
Pugin, 1992, ** [78] |
Trauma ICU, 40 pts |
BAL Endotoxin |
Clinical & BAL |
BAL endotoxin > 6 EU/ml suggests pneumonia due to Gram-negative bacteria. |
|
Flanagan, 2001, ** [77] |
Mixed ICU, 64 pts |
BAL Endotoxin |
Clinical & BAL |
Sens = 81%, spec = 87%, PPV = 67%, NPV = 95%. |
|
|
||||
|
AUC: area under the curve; ICU = intensive care unit; CRP = C-reactive protein; sens = sensitivity; spec = specificity; sTREM-1 = soluble triggering receptor expressed on myeloid cells; BAL = bronchoalveolar lavage; PCT = procalcitonin; EF = elastin fiber; NBLF = non-directed bronchial lavage fluids; EU = endotoxin units; *retrospective; **consecutive; #convenient. |
||||
|
Rea-Neto et al. Critical Care 2008 12:R56 doi:10.1186/cc6877 |
||||
