|
Patient characteristics during the intensive care unit stay |
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| Intention to treat |
Modified intention to treat |
|||||
| Antibiotic treatment n = 22 |
No antibiotic treatment n = 36 |
P value |
Antibiotic treatment n = 18 |
No antibiotic treatment n = 26 |
P value |
|
|
|
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| Tracheostomy |
5 (22) |
5 (13) |
>0.999 |
5 (27) |
5 (19) |
0.716 |
| Corticosteroid use |
8 (36) |
19 (52) |
0.283 |
6 (33) |
13 (50) |
0.359 |
| Septic shock |
1 (4) |
7 (19) |
0.134 |
1 (5) |
5 (19) |
0.375 |
| ICU-acquired infections other than VAT and VAPa |
7 (31) |
18 (50) |
0.274 |
6 (33) |
13 (50) |
0.359 |
| Bacteremia |
6 (27) |
13 (36) |
0.572 |
5 (27) |
8 (30) |
>0.999 |
| Urinary tract infection |
2 (9) |
5 (13) |
0.698 |
2 (11) |
5 (19) |
0.682 |
| Others |
2 (9) |
2 (5) |
>0.999 |
2 (11) |
2 (7) |
>0.999 |
| Total duration of antibiotic treatment, days |
25 ± 14 |
19 ± 15 |
0.149 |
24 ± 15 |
17 ± 15 |
0.104 |
| Antibiotic treatment before VAT |
18 (81) |
29 (80) |
>0.999 |
15 (83) |
23 (88) |
0.676 |
| Antibiotic treatment during the 8 days following random assignment |
22 (100) |
21 (58) |
<0.001 |
18 (100) |
10 (38) |
<0.001 |
| Reasons for antibiotic treatment during the 8 days following random assignment |
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| VAT |
22 (100) |
0 (0) |
<0.001 |
18 (100) |
0 (0) |
<0.001 |
| VAP |
0 (0) |
15 (41) |
<0.001 |
0 (0) |
10 (38) |
0.003 |
| Other infections |
0 (0) |
6 (16) |
0.073 |
0 (0) |
0 (0) |
NA |
| Antibiotic treatment after day 8 post-random assignment |
6 (27) |
8 (22) |
0.756 |
3 (16) |
5 (19) |
>0.999 |
|
Results of univariate analysis are presented. Data are expressed as frequency (percentage) or mean ± standard deviation. aSome patients had more than one ICU-acquired infection. ICU, intensive care unit; NA, not applicable; VAP, ventilator-associated pneumonia; VAT, ventilator-associated tracheobronchitis. | ||||||
Nseir et al. Critical Care 2008 12:R62 doi:10.1186/cc6890 |
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