Table 1 |
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|
Baseline and microbiological characteristics of patients |
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|
Variable |
Dose |
Combined n (%) |
|||
|
|
|||||
|
50,000 U/day |
100,000 U/day |
200,000 U/day |
400,000 U/day |
||
|
|
|||||
|
Number of patients |
4 |
4 |
4 |
4 |
16 |
|
Age (years) |
57.7 ± 17.3 |
61.3 ± 14.2 |
54.3 ± 17.6 |
60.0 ± 13.0 |
58.3 ± 14.3 |
|
Male |
2 |
1 |
4 |
1 |
8 (50) |
|
Acute Physiological and Chronic Health Evaluation II score |
22.3 ± 6.0 |
21.8 ± 8.7 |
18.3 ± 10 |
20.0 ± 3.4 |
20.6 ± 7.0 |
|
Subcutaneous heparin |
4 |
3 |
4 |
3 |
14 (88) |
|
Arterial to inspired oxygen ratio (mmHg) |
159 ± 37 |
143 ± 48 |
207 ± 79 |
226 ± 75 |
183 ± 66 |
|
Lung compliance (ml/cmH2O) |
30 ± 7 |
19 ± 5 |
37 ± 21 |
22 ± 14 |
26 ± 14 |
|
Alveolar dead space fraction |
0.15 ± 0.04 |
0.3 ± 0.10 |
0.17 ± 0.07 |
0.24 ± 0.1 |
0.23 ± 0.1 |
|
Creatinine (μmol/l) |
80 ± 45 |
56 ± 14 |
130 ± 154 |
97 ± 45 |
91 ± 80 |
|
Activated partial thromboplastin time (s) |
38 ± 7 |
37 ± 6 |
44 ± 7 |
47 ± 20 |
41 ± 11 |
|
Thrombin clotting time (s) |
17 ± 2 |
21 ± 3 |
20 ± 10 |
19 ± 3 |
19 ± 5 |
|
Acute lung injury cause |
|||||
|
Pneumonia |
3 |
3 |
2 |
2 |
10 (63) |
|
Sepsis |
0 |
0 |
1 |
1 |
2 (13) |
|
Pancreatitis |
0 |
1 |
0 |
1 |
2 (13) |
|
Empyema |
1 |
0 |
1 |
0 |
2 (13) |
|
Aspiration |
0 |
0 |
0 |
0 |
0 |
|
Surgical admission |
3 |
0 |
1 |
2 |
6 (38) |
|
Microbiology |
|||||
|
Gram-negative |
1 |
0 |
2 |
1 |
4 (25) |
|
Gram-positive |
1 |
2 |
1 |
0 |
4 (25) |
|
Other |
0 |
1 |
0 |
2 |
3 (19) |
|
No pathogen detected |
2 |
1 |
1 |
1 |
5 (31) |
|
Blood culture-positive |
0 |
0 |
1 |
1 |
2 (12) |
|
|
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|
Dixon et al. Critical Care 2008 12:R64 doi:10.1186/cc6894 |
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