|
Patient characteristics |
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| Variables |
All (n = 57) |
Group 1 (n = 10) |
Group 2 (n = 32) |
Group 3 (n = 15) |
P |
|
|
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| Age (years) |
79 (16) |
75 (20) |
80 (12) |
71 (25) |
NS |
| Sex (n; male/female) |
33/24 |
7/3 |
16/16 |
10/5 |
NS |
| First cortisol level (μg/dl) |
42.9 (14.8) |
49.3 (27.7) |
41.4 (17.3) |
42.0 (20.9) |
NS |
| Second cortisol level (μg/dl) |
22.3 (15.8) |
45.1 (25.5) |
23.4 (9.3) |
9.6 (8.8) |
< 0.05 |
| Change in cortisol level (μg/dl) |
24.7 (28.7) |
0.8 (13.3) |
21.1 (16.9) |
34.8 (16.7) |
< 0.05 |
| Time interval between both cortisol tests (days) |
8 (5) |
8 (3) |
8 (6) |
9 (5) |
NS |
| Etiologies (n) |
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| Pneumonia |
23 |
5 |
11 |
7 |
NS |
| Chronic obstructive pulmonary disease with acute exacerbation |
3 |
0 |
1 |
2 |
NS |
| Sepsis |
15 |
2 |
8 |
5 |
NS |
| Hypovolemic shock |
3 |
0 |
3 |
0 |
NS |
| Cerebrovascular accident |
2 |
0 |
1 |
1 |
NS |
| Congestive heart failure |
3 |
0 |
3 |
0 |
NS |
| Arrhythmia |
3 |
1 |
2 |
0 |
NS |
| Acute myocardial infarction |
5 |
2 |
3 |
0 |
NS |
| Diabetes mellitus (n) |
17 |
4 |
12 |
1 |
NS |
| Malignancy (n) |
12 |
1 |
10 |
1 |
NS |
| First albumin level (g/dL) |
3.0 (0.7) |
3.0 (0.6) |
2.9 (1.0) |
3.0 (0.7) |
NS |
| Second albumin level (g/dL) |
2.8 (0.8) |
2.6 (0.5) |
2.9 (1.1) |
2.8 (0.6) |
NS |
| First SOFA score |
9 (5) |
10 (8) |
9 (6) |
8 (3) |
NS |
| Second SOFA score |
10 (5) |
13 (9) |
10 (6) |
9 (3) |
NS |
| First APACHE II score |
21 (8) |
22 (11) |
21 (8) |
19 (9) |
NS |
| Second APACHE II score |
21 (9) |
22 (10) |
21 (7) |
18 (10) |
NS |
| Change in body temperature (°C) |
0.0 (1.1) |
0.2 (3.1) |
0.0 (0.8) |
0.0 (1.0) |
NS |
| First dopamine dosage (μg/kg/min) |
6.0 (11.0) |
6.0 (20.0) |
5.0 (4.8) |
6.0 (13.0) |
NS |
| Second dopamine dosage (μg/kg/min) |
4.0 (8.0) |
5.0 (10.0) |
3.5 (6.8) |
4.0 (9.0) |
NS |
| First norepinephrine dosage (μg/min) |
2.0 (1.0) |
4.0 (4.0) |
2.0 (1.0) |
2.0 (1.0) |
NS |
| Second norepinephrine dosage (μg/min) |
3.0 (4.5) |
3.5 (8.5) |
2.0 (1.0) |
4.0 (6.0) |
NS |
| Mortality (n [%]) |
32 (56%) |
6 (60%) |
17 (53%) |
9 (60%) |
NS |
| Ventilator dependent (n [%]) |
7 (12%) |
1 (10%) |
3 (9%) |
3 (20%) |
NS |
| Mean ICU LOS (days) |
28 (27) |
23 (23) |
26 (18) |
41 (29) |
NS |
| Mean hospital LOS (day) |
41 (48) |
32 (22) |
35 (36) |
69 (26) |
NS |
|
Unless otherwise stated, variables are presented as median (interquartile range). APACHE, Acute Physiology and Chronic Health Evaluation; LOS, length of stay; NS, nonsignificant; SOFA, Sequential Organ Failure Assessment. | |||||
Wu et al. Critical Care 2008 12:R65 doi:10.1186/cc6895 |
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