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Characteristics of the study population |
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| Characteristic |
Group A (control individuals; n = 26) |
Group B (moderate brain injury; n = 18) |
Group C (severe brain injury; n = 32) |
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| Age (years; mean ± SD) |
49 ± 19 |
43 ± 14 |
49 ± 18 |
| Sex (male/female; n) |
21/5 |
12/6 |
25/7 |
| BMI (kg/m2; mean ± SD) |
20 ± 4.9 |
20 ± 4.5 |
19.2 ± 6.0 |
| GCS (1 to 14; median [range]) |
14 |
11.1 (8 to 13) |
4.9 (3 to 7)* |
| Diagnosis upon admission (n [%]) |
Trauma: 11 (42%) |
Head injury: 18 (100%) |
Head injury: 32 (100%) |
| Sepsis: 8 (31%) |
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| ARDS: 5 (19%) |
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| Burn: 2 (8%) |
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| ONSD (mm; mean ± SD [range]) |
3.6 ± 0.6 (2.2 to 4.9) |
4.2 ± 1.2 (3.0 to 6.2) |
6.1 ± 0.7 (5.2 to 7.8)* |
| eICP (mmHg; mean ± SD [range]) |
10.3 ± 3.1 (3.5 to 14.7) |
12.0 ± 3.6 (6.3 to 18.4) |
26.2 ± 8.7 (14.4 to 51.1)† |
| ICP (mmHg; mean ± SD [range]) |
- |
- |
26.0 ± 7.3 (16.0 to 47.0) |
| CPP (mmHg; mean ± SD [range]) |
- |
- |
61.8 ± 12.0 (29.0 to 85.0) |
| Brain CT injury scale upon admission (I to VI; n [%]) |
Normal |
I: 18 (100%) |
II: 4 (12.5%) |
| III: 16 (50.0%) |
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| IV: 4 (12.5%) |
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| V: 4 (12.5%) |
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| VI: 4 (12.5%) |
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*Statistically significant difference in GCS and ONSD values between group C and groups A and B (P < 0.0001; Student's t-test). †Statistically significant difference in eICP values between group C and groups A and B (P < 0.0001; Student's t-test). ARDS, adult respiratory distress syndrome; BMI, body mass index; CPP, cerebral perfusion pressure; CT, computed tomography; eICP, non-invasive intracranial pressure; GCS, Glasgow Coma Scale; ICP, invasive intracranial pressure; ONSD, optic nerve sheath diameter; SD, standard deviation. | |||
Soldatos et al. Critical Care 2008 12:R67 doi:10.1186/cc6897 |
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