Table 6

Classification of serum HMGB1, number of SIRS criteria, SAPS II score and PaO₂/FiO₂ ratio according to the HMGB1 982C>T and -1377delA genotypes

Variable

982C>T genotype

-1377delA genotype

C/C

C/T

A/A

A/- or -/-

Serum HMGB1 (ng/μl)

1.45 ± 3.05

0.28 ± 0.96*

1.36 ± 2.78

1.61 ± 4.43

Number of SIRS criteria

3.13 ± 0.81

3.83 ± 0.39*

3.21 ± 0.80

2.76 ± 0.78*

SAPS II

37.8 ± 15.2

43.9 ± 12.3

38.2 ± 15.3

36.8 ± 13.8

PaO₂/FiO₂ ratio

164 ± 94

89 ± 38*

158 ± 96

182 ± 63

Data presented as mean ± standard deviation. *P = 0.01. HMGB1, high mobility group box 1 protein; PaO₂/FiO₂ = ratio between partial pressure of oxygen and fraction of inspired oxygen; SAPS II, Simplified Acute Physiology score II; SIRS, systemic inflammatory response syndrome.

Kornblit et al. Critical Care 2008 12:R83   doi:10.1186/cc6935