How to prevent leaky vessels during reperfusion? Just keep that glycocalyx sealant in place!

doi:10.1186/cc6939

Critical Care
Volume 12
Issue 4

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Commentary

How to prevent leaky vessels during reperfusion? Just keep that glycocalyx sealant in place!

Jurgen WGE VanTeeffelen

Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, UNS 50, 6229 ER Maastricht, PO Box 616, 6200 MD Maastricht, the Netherlands

author email corresponding author email

Critical Care 2008, 12:167doi:10.1186/cc6939


Published:	15 July 2008

See related research by Bruegger et al., http://ccforum.com/content/12/3/R73

Abstract

Myocardial edema is a hallmark of ischemia-reperfusion-related cardiac injury. Ischemia-reperfusion has been shown to result in degradation of the endothelial glycocalyx. The glycocalyx is the gel-like mesh of polysaccharide structures and absorped plasma proteins on the luminal side of the vasculature, and in the past decade has been shown to play an important role in protection of the vessel wall, including its barrier properties. Prevention of glycocalyx loss or restoration of a damaged glycocalyx may be a promising therapeutic target during clinical procedures involving ischemia-reperfusion.