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Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate?

Giuseppe Lippi* and Gian Cesare Guidi

Author Affiliations

Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi, Piazzale Scuro 10, 37134 Verona, Italy

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Critical Care 2008, 12:423 doi:10.1186/cc6936

Published: 25 July 2008

First paragraph (this article has no abstract)

Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Although several groups are working on developing and validating biomarkers of kidney injury and the glomerular filtration rate (GFR), the proposed diagnostic criteria from the Acute Kidney Injury Network are based on an absolute increase in serum creatinine ≥ 0.3 mg/dl (≥ 26.4 μmol/l), a percentage increase in serum creatinine ≥ 50% (1.5-fold from baseline), or a reduction in urine output (documented oliguria < 0.5 ml/kg per hour for more than 6 hours) [1].