Figure 7.

High-molecular-weight hyaluronan (1,600 kDa) given after lipopolysaccharide infusion blocked lung injury in a dose-dependent manner. Animals were infused with 0.025%, 0.05%, or 0.1% high-molecular-weight hyaluronan (HMW HA) or 0.1% sodium carboxymethyl cellulose (CMC) at 500 ml/hour starting 1 hour after lipopolysaccharide (LPS) infusion. *P < 0.05 versus LPS, #P < 0.05 versus LPS + 0.1% HMW HA.