Table 2

Hemodynamics in the treatment model

Systolic blood pressure

Heart rate

Group

Baseline

4 hours

Baseline

4 hours

Control

125 ± 6

88 ± 6

425 ± 25

327 ± 9

LPS alone

98 ± 8

70 ± 5

465 ± 11

438 ± 28*

LPS + 0.025% of 1,600 kDa HMW HA

125 ± 5

72 ± 8

442 ± 21

448 ± 9*

LPS + 0.5% of 1,600 kDa HMW HA

112 ± 9

86 ± 6

475 ± 17

445 ± 10*

LPS + 0.1% of 1,600 kDa HMW HA

97 ± 16

87 ± 6

495 ± 18

401 ± 23*

LPS + 0.1% sodium carboxymethyl cellulose

97 ± 8

85 ± 7

464 ± 18

474 ± 30* ^†

There were no statistical differences between groups for systolic blood pressure. In the lipopolysaccharide (LPS)-exposed groups the heart rate was statistically higher, but there were no statistical differences between the high-molecular-weight hyaluronan (HMW HA) treatment groups. LPS + 0.1% sodium carboxymethyl cellulose was statistically higher than LPS + 0.1% HMW HA. *P < 0.01 versus control. ^†P < 0.01 versus LPS + 0.1% HMW HA.

Liu et al. Critical Care 2008 12:R102   doi:10.1186/cc6982