Figure 9.

Differences in signaling pathway activation of mechanical ventilation with bleomycin. The serine/threonine kinase/protein kinase B (Akt) and extracellular signal-regulated kinase (ERK) 1/2 pathways were involved in high-tidal-volume ventilation-augmented pulmonary fibrosis after bleomycin-induced acute lung injury, type III procollagen mRNA expression, microvascular permeability, and production of murine macrophage inflammatory protein-2 (MIP-2), but not 10 kDa IFNγ-inducible protein (IP-10) production.