Figure 1.

Changes in pulmonary vascular pressures and fluid filtration in awake, endotoxemic sheep. rhAPC, recombinant human activated protein C alone group (n = 4); LPS, lipopolysaccharide group (n = 8); LPS + rhAPC, rhAPC-treated LPS group (n = 9). Data presented as the mean ± standard error of the mean. PAP, pulmonary arterial pressure; Pmo, pulmonary micro-occlusion pressure; PVRIup, upstream pulmonary vascular resistance index; PVRIdwn, downstream pulmonary vascular resistance index; EVLWI, extravascular lung water index; PVPI, pulmonary vascular permeability index. †P < 0.05 between the LPS and the LPS + rhAPC groups; ‡P < 0.05 from t = 0 hours in the LPS group; §P < 0.05 from t = 4 hours in the LPS group; *P < 0.05 from t = 0 hours in the LPS + rhAPC group; #P < 0.05 from t = 4 hours in the LPS + rhAPC group.