Table 1

Hemodynamic variables in instrumented awake sheep
Variable
 Time


0 hour
 1 hour
 4 hours
 8 hours
 12 hours
 16 hours
 20 hours
 24 hours
PVRI (dyne/s/cm5/m2)







     rhAPC
 194 ± 22
 192 ± 22
 179 ± 38
 198 ± 58
 202 ± 40
 193 ± 38
 195 ± 33
 166 ± 20
     LPS
 188 ± 12
 810 ± 94*
 359 ± 31*
 252 ± 29
 227 ± 21
 266 ± 35
 268 ± 54
 248 ± 56
     LPS + rhAPC
 201 ± 10
 847 ± 124*
 392 ± 44*
 215 ± 29†
 224 ± 39†
 209 ± 41†
 229 ± 38†
 210 ± 41†
PAOP (mmHg)







     rhAPC
 8 ± 0
 8 ± 0
 9 ± 0
 8 ± 1
 10 ± 0
 9 ± 1
 9 ± 1
 8 ± 1
     LPS
 8 ± 0
 18 ± 1*
 12 ± 0*
 12 ± 1*
 12 ± 1*
 12 ± 1*
 13 ± 1*
 11 ± 0*
     LPS + rhAPC
 8 ± 1
 15 ± 2*
 12 ± 1*
 11 ± 1*
 10 ± 1*
 11 ± 1*
 11 ± 1*
 10 ± 1
RAP (mmHg)







     rhAPC
 3 ± 0
 3 ± 1
 6 ± 1*
 5 ± 1*
 5 ± 1
 5 ± 1*
 5 ± 0*
 5 ± 1
     LPS
 4 ± 1
 5 ± 1
 7 ± 1*
 7 ± 2
 7 ± 1*
 7 ± 1*
 8 ± 1*
 8 ± 1*
     LPS + rhAPC
 3 ± 1
 2 ± 1
 6 ± 1*
 5 ± 1*
 6 ± 1*
 6 ± 1*
 6 ± 2*
 5 ± 2
Heart rate (beats/min)







     rhAPC
 94 ± 8
 91 ± 8
 95 ± 6
 92 ± 7
 95 ± 4
 97 ± 5
 97 ± 6
 92 ± 7
     LPS
 106 ± 4
 139 ± 14
 129 ± 7
 151 ± 9
 134 ± 8
 127 ± 7
 142 ± 12
 137 ± 11
     LPS + rhAPC
 94 ± 5
 158 ± 16*
 112 ± 9*
 151 ± 10* †
 138 ± 11* †
 128 ± 12*
 122 ± 13
 123 ± 12
MAP (mmHg)







     rhAPC
 103 ± 3
 100 ± 4
 103 ± 3
 106 ± 5
 106 ± 2
 101 ± 3
 105 ± 1
 100 ± 5
     LPS
 101 ± 3
 107 ± 5
 110 ± 3*
 90 ± 3* †
 88 ± 4* †
 93 ± 3†
 91 ± 3* †
 90 ± 3* †
     LPS + rhAPC
 101 ± 3
 105 ± 4
 108 ± 2
 95 ± 4
 95 ± 4
 96 ± 5
 95 ± 4
 98 ± 5
SVRI (dyne/s/cm5/m2)







     rhAPC
 1677 ± 70
 1688 ± 82
 1610 ± 108
 1877 ± 327
 1918 ± 302
 1680 ± 204
 1872 ± 186
 1671 ± 268
     LPS
 1587 ± 69
 1976 ± 165*
 1962 ± 90*
 1212 ± 87* †
 1089 ± 82* †
 1278 ± 101* †
 1267 ± 139* †
 1194 ± 111* †
     LPS + rhAPC
 1559 ± 68
 1789 ± 153
 1910 ± 107*
 1302 ± 153†
 1226 ± 121†
 1268 ± 119†
 1337 ± 141†
 1367 ± 135†
Cardiac index (l/min/m2)







     rhAPC
 5.4 ± 0.6
 5.3 ± 0.7
 5.2 ± 0.4
 5.0 ± 0.8
 5.0 ± 0.7
 5.2 ± 0.6
 4.9 ± 0.6
 5.1 ± 0.6
     LPS
 5.3 ± 0.3
 5.0 ± 0.7
 4.3 ± 0.2*
 6.0 ± 0.5†
 6.0 ± 0.2†
 5.7 ± 0.3†
 5.9 ± 0.5†
 6.0 ± 0.5†
     LPS + rhAPC
 5.1 ± 0.3
 4.9 ± 0.4
 4.3 ± 0.2
 5.8 ± 0.3†
 6.1 ± 0.4†
 5.9 ± 0.4†
 5.7 ± 0.5†
 5.8 ± 0.5†
SVI (ml/beat/m2)







     rhAPC
 57 ± 3
 57 ± 2
 55 ± 2
 54 ± 6
 52 ± 7
 55 ± 7
 52 ± 8
 57 ± 8
     LPS
 49 ± 2
 36 ± 2*
 33 ± 2*
 40 ± 4
 46 ± 3
 45 ± 2
 44 ± 5
 46 ± 4
     LPS + rhAPC
 55 ± 2
 33 ± 4*
 40 ± 3*
 39 ± 3*
 46 ± 4*
 49 ± 5
 50† ± 5
 49 ± 5
LAP (mmHg)







     rhAPC
 5 ± 1
 5 ± 1
 6 ± 2
 6 ± 1
 6 ± 1
 6 ± 1
 6 ± 1
 7 ± 1
     LPS
 5 ± 1
 5 ± 1
 8 ± 1*
 8 ± 1*
 8 ± 1*
 9 ± 1*
 9 ± 1*
 9 ± 1*
     LPS + rhAPC
 5 ± 1
 3 ± 1
 6 ± 1
 9 ± 2*
 8 ± 2*
 9 ± 2*
 8 ± 2*
 9 ± 2*
LVSWI (g/m/m2)







     rhAPC
 67 ± 3
 69 ± 4
 68 ± 3
 69 ± 12
 62 ± 8
 63 ± 11
 61 ± 12
 64 ± 11
     LPS
 62 ± 3
 42 ± 3*
 44 ± 2*
 43 ± 4*
 49 ± 5
 50 ± 3*
 47 ± 6*
 49 ± 5*
     LPS + rhAPC
 69 ± 4
 42 ± 6*
 52 ± 4*
 44 ± 3*
 53 ± 4*
 56 ± 5*
 56 ± 5*
 59 ± 7
RVSWI (g/m/m2)







     rhAPC
 11 ± 1
 11 ± 1
 9 ± 1
 9 ± 1
 9 ± 1
 9 ± 1
 9 ± 1
 10 ± 2
     LPS
 9 ± 0
 22 ± 1*
 9 ± 0
 11 ± 1
 12 ± 1
 12 ± 1*
 11 ± 1
 10 ± 1
     LPS + rhAPC
 10 ± 1
 21 ± 2*
 11 ± 1
 9 ± 1
 11 ± 1
 10 ± 1
 11 ± 2
 11 ± 2

Data presented as the mean ± standard error of the mean. rhAPC, recombinant human activated protein C alone (n = 4); LPS, lipopolysaccharide group (n = 8); LPS + rhAPC, rhAPC-treated LPS group (n = 9); PVRI, pulmonary vascular resistance index; PAOP, pulmonary arterial occlusion pressure; RAP, right atrial pressure; MAP, mean arterial pressure; SVRI, systemic vascular resistance index; SVI, stroke volume index; LAP, left atrial pressure; LVSWI, left ventricle stroke work index; RVSWI, right ventricle stroke work index. *P < 0.05 from t = 0 hours. †P < 0.05 from t = 4 hours.

Waerhaug et al. Critical Care 2008 12:R104   doi:10.1186/cc6985