Table 2

Respiratory and metabolic variables in instrumented awake sheep

Time


0 hours
 4 hours
 8 hours
 12 hours
 16 hours
 20 hours
 24 hours
SaO2 (%)






     rhAPC
 96 ± 3
 95 ± 3
 98 ± 1
 99 ± 1
 98 ± 1
 98 ± 1
 99 ± 1
     LPS
 98 ± 0
 98 ± 1
 98 ± 1
 98 ± 1
 98 ± 1
 97 ± 2
 97 ± 2
     LPS + rhAPC
 98 ± 0
 96 ± 1
 98 ± 0
 98 ± 1
 97 ± 1
 97 ± 1
 98 ± 1
SvO2 (%)






     rhAPC
 61 ± 4
 59 ± 4
 61 ± 5
 59 ± 5
 61 ± 4
 61 ± 5
 63 ± 4
     LPS
 62 ± 3
 62 ± 3
 69 ± 2* †
 67 ± 3*
 64 ± 3
 63 ± 3
 61 ± 3
     LPS + rhAPC
 63 ± 3
 61 ± 3
 70 ± 3†
 66 ± 2†
 67 ± 2* †
 66 ± 2
 67 ± 2* †
DO2I (ml/min/m2)






     rhAPC
 640 ± 64
 649 ± 7
 626 ± 85
 573 ± 63
 614 ± 39
 595 ± 72
 654 ± 54
     LPS
 608 ± 32
 585 ± 48
 785 ± 53*
 763 ± 62*
 731 ± 45*
 748 ± 70*
 751 ± 73*
     LPS + rhAPC
 642 ± 52
 611 ± 38
 802 ± 76* †
 772 ± 58†
 732 ± 51†
 693 ± 51
 704 ± 55
VO2I (ml/min/m2)






     rhAPC
 225 ± 37
 244 ± 26
 243 ± 63
 222 ± 46
 215 ± 28
 206 ± 12
 218 ± 28
     LPS
 226 ± 7
 207 ± 11
 232 ± 15
 234 ± 14
 252 ± 19
 261 ± 24
 277 ± 30
     LPS + rhAPC
 229 ± 26
 231 ± 22
 225 ± 21
 249 ± 20
 232 ± 17
 227 ± 19
 227 ± 22
Qs/Qt






     rhAPC
 0.12 ± 0.06
 0.13 ± 0.06
 0.05 ± 0.02
 0.04 ± 0.02
 0.08 ± 0.02
 0.04 ± 0.01
 0.02 ± 0.01
     LPS
 0.05 ± 0.01
 0.11 ± 0.03
 0.13 ± 0.03
 0.13 ± 0.04
 0.12 ± 0.04
 0.10 ± 0.04
 0.10 ± 0.04
     LPS + rhAPC
 0.07 ± 0.01
 0.11 ± 0.02
 0.10 ± 0.01
 0.08 ± 0.03
 0.10 ± 0.03
 0.09 ± 0.03
 0.08 ± 0.03
Arterial pH






     rhAPC
 7.50 ± 0.01
 7.47 ± 0.01
 7.44 ± 0.03
 7.44 ± 0.04
 7.45 ± 0.03
 7.49 ± 0.02
 7.48 ± 0.02
     LPS
 7.51 ± 0.01
 7.55 ± 0.01
 7.54 ± 0.01
 7.54 ± 0.01
 7.52 ± 0.03
 7.53 ± 0.03
 7.53 ± 0.03
     LPS + rhAPC
 7.49 ± 0.02
 7.54 ± 0.01*
 7.51 ± 0.01
 7.49 ± 0.01†
 7.50 ± 0.01†
 7.52 ± 0.01* †
 7.51 ± 0.01†
PaCO2 (kPa)






     rhAPC
 33 ± 2
 33 ± 1
 33 ± 1
 34 ± 2
 35 ± 1
 33 ± 1
 33 ± 1
     LPS
 36 ± 1
 35 ± 3
 33 ± 1
 33 ± 1
 34 ± 1
 34 ± 1
 35 ± 1
     LPS + rhAPC
 36 ± 1
 31 ± 2*
 32 ± 1*
 34 ± 2
 36 ± 2†
 35 ± 2†
 35 ± 2†
Hemoglobin (g/dl)






     rhAPC
 9.1 ± 1.2
 9.1 ± 1.3
 9.2 ± 1.2
 8.7 ± 1.0
 8.9 ± 1.1
 9.2 ± 1.1
 9.3 ± 1.1
     LPS
 8.7 ± 0.7
 10.4 ± 0.6*
 10,3 ± 0.7*
 9.6 ± 0.6* †
 9.7 ± 0.7*
 9.7 ± 0.6*
 9.6 ± 0.7*
     LPS + rhAPC
 9.5 ± 0.6
 10.8 ± 0.6*
 10.2 ± 0.6†
 9.6 ± 0.6†
 9.4 ± 0.5†
 9.3 ± 0.4†
 9.4 ± 0.5†
Temperature (°C)






     rhAPC
 39.4 ± 0.1
 39.4 ± 0.1
 39.3 ± 0.2
 39.4 ± 0.2
 39.3 ± 0.2
 39.2 ± 0.2
 39.1 ± 0.1
     LPS
 39.2 ± 0.2
 40.8 ± 0.3*
 40.2 ± 0.2*
 40.3 ± 0.2*
 40.5 ± 0.2*
 40.3 ± 0.3*
 40.1 ± 0.2*
     LPS + rhAPC
 39.1 ± 0.1
 41.0 ± 0.3*
 40.2 ± 0.2* †
 40.0 ± 0.1* †
 40.0 ± 0.1* †
 40.0 ± 0.2* †
 39.9 ± 0.2* †
Antithrombin III plasma concentration (%)






     rhAPC
 70 ± 2
 74 ± 2
70 ± 2

70 ± 3
     LPS
 79 ± 3
 71 ± 4*
66 ± 4* †

63 ± 4* †
     LPS + rhAPC
 69 ± 3
 69 ± 3
62 ± 3* †

58 ± 2* †

Data presented as the mean ± standard error of the mean. rhAPC, recombinant human activated protein C alone group (n = 4); LPS, lipopolysaccharide group (n = 8); LPS + rhAPC, rhAPC-treated LPS group (n = 9). SaO2, arterial oxygen saturation; SvO2, central venous oxygen saturation; DO2I, oxygen delivery index; VO2I, oxygen consumption index; Qs/Qt, venous admixture. *P < 0.05 from t = 0 hours. †P < 0.05 from t = 4 hours.

Waerhaug et al. Critical Care 2008 12:R104   doi:10.1186/cc6985