Table 3

Lung injury score in instrumented awake sheep

Variable

Edema

Neutrophil infiltration

Hemorrhage

Epithelial desquamation

Hyaline membranes

Lung injury score

rhAPC

1.3 (1.0 to 2.0)

0.5 (0.0 to 2.0)

1.0 (0.0 to 3.0)

0.5 (0.0 to 1.0)

0.0 (0.0 to 1.0)

3.8 (2.0 to 6.5)

LPS

2.0 (1.0 to 3.0)

2.5 (0.5 to 3.5)*

0.8 (0.0 to 2.0)

1.0 (0.5 to 4.0)*

1.0 (0.0 to 2.0)*

6.8 (2.5 to 11.5)*

LPS + rhAPC

1.0 (0.5 to 2.0)^†

1.0 (0.0 to 2.0)^†

1.0 (0.0 to 2.0)

1.0 (0.5 to 2.0)

0.5 (0.0 to 2.0)

4.5 (1.5 to 8.5)^†

Data presented as the median (minimum to maximum). rhAPC, recombinant human activated protein C alone group (n = 4); LPS, lipopolysaccharide group (n = 8); LPS + rhAPC, rhAPC-treated LPS group (n = 9). The histological markers of lung injury are scored on a scale from zero to four. *P < 0.05 between the LPS and the rhAPC groups. ^†P < 0.05 between the LPS and the LPS + rhAPC groups.

Waerhaug et al. Critical Care 2008 12:R104   doi:10.1186/cc6985