Table 3

Pooled summary results of the prognostic value of elevated brain natriuretic peptide in acute pulmonary embolism

Endpoints

OR (95% CI)

Sensitivity (95% CI)

Specificity (95% CI)

LR+ (95% CI)

LR- (95% CI)

PPV (95% CI)

NPV (95% CI)

Short-term death (12 studies, 868 patients)

6.57 (3.11–13.91)

0.93 (0.85–0.98)

0.48 (0.44–0.51)

1.64 (1.39–1.94)

0.34 (0.19–0.61)

0.14 (0.11–0.18)

0.99 (0.97–1.00)

Death resulting from PE (10 studies, 684 patients)

6.10 (2.58–14.25)

0.92 (0.81–0.98)

0.52 (0.48–0.56)

1.76 (1.33–2.34)

0.37 (0.19–0.71)

0.13 (0.10–0.17)

0.99 (0.97–1.00)

Serious adverse events (9 studies, 688 patients)

7.47 (4.2–13.15)

0.89 (0.83–0.93)

0.48 (0.44–0.52)

1.70 (1.44–2.01)

0.28 (0.17–0.48)

0.33 (0.29–0.38)

0.94 (0.90–0.96)

CI, confidence interval; LR+, positive likelihood ratio; LR-, negative likelihood ratio; NPV, negative predictive value; OR, odds ratio; PE, pulmonary embolism; PPV, positive predictive value.

Coutance et al. Critical Care 2008 12:R109   doi:10.1186/cc6996