Table 8

Separate multivariate regression analysis for the Risk, Injury, Failure, Loss of Kidney Function, End-stage Kidney Disease (RIFLE) and the Acute Kidney Injury Network (AKIN) classifications

Criteria

Hospital mortality (odds ratio (95% confidence interval))

P value

Area under receiver operator characteristic curve

RIFLE criteria (creatinine + urine output)

Risk

2.69 (1.49 to 4.88)

0.001

0.733

Injury

2.01 (1.03 to 3.89)

0.038

Failure

3.59 (2.01 to 6.42)

< 0.0001

Any category

2.78 (1.74 to 4.45)

< 0.0001

AKIN criteria (creatinine + urine output)

Stage 1

3.54 (1.97 to 6.37)

< 0.0001

0.750

Stage 2

2.71 (1.33 to 5.53)

0.006

Stage 3

4.66 (2.49 to 8.73)

< 0.0001

Any stage

3.59 (2.14 to 6.01)

< 0.0001

RIFLE criteria (creatinine)

Risk

2.63 (1.46 to 4.75)

0.001

0.729

Injury

2.12 (1.1 to 4.08)

0.025

Failure

3.2 (1.8 to 5.7)

< 0.0001

Any category

2.68 (1.69 to 4.25)

< 0.0001

AKIN criteria (creatinine)

Stage 1

3.18 (1.79 to 5.64)

< 0.0001

0.745

Stage 2

2.74 (1.35 to 5.56)

0.005

Stage 3

3.93 (2.12 to 7.28)

< 0.0001

Any stage

3.38 (2.05 to 5.57)

< 0.0001

RIFLE criteria (urine output)

Risk

1.3 (0.35 to 4.8)

0.689

0.619

Injury

0.83 (0.31 to 2.21)

0.711

Failure

3.26 (1.74 to 6.13)

< 0.0001

Any category

2.06 (1.24 to 3.42)

0.005

AKIN criteria (urine output)

Stage 1

1.03 (0.3 to 3.58)

0.953

0.612

Stage 2

1.03 (0.35 to 2.99)

0.953

Stage 3

2.65 (1.45 to 4.84)

0.001

Any stage

1.9 (1.16 to 3.14)

0.01

Defined by both creatinine and urine output criteria or by creatinine criteria or by urine output criteria, including age, gender, race, history of cardiovascular disease, medical admission, sepsis diagnosis, illness severity evaluated by Simplified Acute Physiology Score version II, and need for vasopressors or for mechanical ventilation.

Lopes et al. Critical Care 2008 12:R110   doi:10.1186/cc6997