Table 8

Separate multivariate regression analysis for the Risk, Injury, Failure, Loss of Kidney Function, End-stage Kidney Disease (RIFLE) and the Acute Kidney Injury Network (AKIN) classifications
Criteria
 Hospital mortality (odds ratio (95% confidence interval))
 P value
 Area under receiver operator characteristic curve
RIFLE criteria (creatinine + urine output)


     Risk
 2.69 (1.49 to 4.88)
 0.001
 0.733
     Injury
 2.01 (1.03 to 3.89)
 0.038
     Failure
 3.59 (2.01 to 6.42)
 < 0.0001
     Any category
 2.78 (1.74 to 4.45)
 < 0.0001
AKIN criteria (creatinine + urine output)


     Stage 1
 3.54 (1.97 to 6.37)
 < 0.0001
 0.750
     Stage 2
 2.71 (1.33 to 5.53)
 0.006
     Stage 3
 4.66 (2.49 to 8.73)
 < 0.0001
     Any stage
 3.59 (2.14 to 6.01)
 < 0.0001
RIFLE criteria (creatinine)


     Risk
 2.63 (1.46 to 4.75)
 0.001
 0.729
     Injury
 2.12 (1.1 to 4.08)
 0.025
     Failure
 3.2 (1.8 to 5.7)
 < 0.0001
     Any category
 2.68 (1.69 to 4.25)
 < 0.0001
AKIN criteria (creatinine)


     Stage 1
 3.18 (1.79 to 5.64)
 < 0.0001
 0.745
     Stage 2
 2.74 (1.35 to 5.56)
 0.005
     Stage 3
 3.93 (2.12 to 7.28)
 < 0.0001
     Any stage
 3.38 (2.05 to 5.57)
 < 0.0001
RIFLE criteria (urine output)


     Risk
 1.3 (0.35 to 4.8)
 0.689
 0.619
     Injury
 0.83 (0.31 to 2.21)
 0.711
     Failure
 3.26 (1.74 to 6.13)
 < 0.0001
     Any category
 2.06 (1.24 to 3.42)
 0.005
AKIN criteria (urine output)


     Stage 1
 1.03 (0.3 to 3.58)
 0.953
 0.612
     Stage 2
 1.03 (0.35 to 2.99)
 0.953
     Stage 3
 2.65 (1.45 to 4.84)
 0.001
     Any stage
 1.9 (1.16 to 3.14)
 0.01

Defined by both creatinine and urine output criteria or by creatinine criteria or by urine output criteria, including age, gender, race, history of cardiovascular disease, medical admission, sepsis diagnosis, illness severity evaluated by Simplified Acute Physiology Score version II, and need for vasopressors or for mechanical ventilation.

Lopes et al. Critical Care 2008 12:R110   doi:10.1186/cc6997