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Adverse events during barbiturate coma |
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| Adverse event |
Thiopental (n = 22) |
Pentobarbital (n = 22) |
P |
|
|
|||
| Hypotensiona |
21 |
20 |
1 |
| Respiratory infectionb |
18 |
17 |
1 |
| Urinary infectionc |
0 |
2 |
0.49 |
| Positive blood culture |
4 |
1 |
0.34 |
| ICP catheter colonization |
7 |
5 |
0.5 |
| CNS infection (CSF)d |
3 |
0 |
0.23 |
| SOFA pree |
7 (4.5 to 9.5) |
8.0 (5.5 to 9.0) |
0.57 |
| SOFA maximumf |
11 (10 to 12) |
11 (10 to 12) |
0.94 |
|
aHypotension is defined as detection of a medium arterial blood pressure below 80 mmHg at any time during barbiturate coma. bRespiratory infection: presence of a positive sputum culture. cUrinary infection: presence of a positive urine culture. dCentral nervous system infection (CNS) infection (cerebrospinal fluid [CSF]): infection of the CNS with a positive culture in the CSF. eSOFA pre: value of the Sepsis related Organ-Failure Assessment (SOFA) score before the beginning of the barbiturate coma. fSOFA maximum: maximum value of the SOFA during the barbiturate coma, according the indication by Moreno and coworkers [16]. | |||
Pérez-Bárcena et al. Critical Care 2008 12:R112 doi:10.1186/cc6999 |
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