Table 5 |
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|
Systemic changes during barbiturate coma |
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|
Parameter |
Pretreatment |
1st day |
2nd day |
3rd day |
4rd day |
|
|
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|
Cardiac output (l/minute)a |
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|
Thiopental |
6.8 ± 1.4 |
6.4 ± 1.5 |
6.0 ± 1.4 |
6.7 ± 1.5 |
6.6 ± 1.8 |
|
Pentobarbital |
7.4 ± 2.2 |
7.1 ± 1.9 |
6.5 ± 2.0 |
7 ± 1.4 |
6.1 ± 1.3 |
|
Cardiac index (l/minute per m2) |
|||||
|
Thiopental |
3.6 ± 0.6 |
3.4 ± 0.6 |
3.1 ± 0.6 |
3.6 ± 1.6 |
3.5 ± 0.9 |
|
Pentobarbital |
3.8 ± 1.2 |
3.8 ± 0.8 |
3.4 ± 0.8 |
3.6 ± 0.7 |
3.2 ± 0.6 |
|
Peripheral venous resistance (dines/m2) |
|||||
|
Thiopental |
1,015 ± 325 |
1,022 ± 347 |
1,140 ± 429 |
1,089 ± 289 |
1,029 ± 253 |
|
Pentobarbital |
952 ± 257 |
893 ± 210 |
1,003 ± 322 |
939 ± 261 |
914 ± 188 |
|
Pulmonary artery wedge pressure (mmHg) |
|||||
|
Thiopental |
10.4 ± 4.5 |
9.6 ± 3.6 |
10.1 ± 4.1* |
10.9 ± 4.6* |
11.4 ± 3.5* |
|
Pentobarbital |
11.6 ± 4.0 |
11.4 ± 3.1 |
12.8 ± 3.1 |
13.2 ± 2.1 |
13.9 ± 3.1 |
|
mBP (mmHg)b |
|||||
|
Thiopental |
92 ± 11 |
75 ± 7 |
76 ± 9* |
76 ± 6* |
76 ± 8 |
|
Pentobarbital |
94 ± 10 |
74 ± 1 |
68 ± 10 |
70 ± 1 |
70 ± 10 |
|
NAD (μg/kg per minute)c |
|||||
|
Thiopental |
0.18 ± 0.33 |
0.28 ± 0.27 |
0.37 ± 0.3* |
0.46 ± 0.39 |
0.56 ± 0.63 |
|
Pentobarbital |
0.19 ± 0.18 |
0.55 ± 0.68 |
0.73 ± 0.69 |
0.60 ± 0.44 |
0.96 ± 0.79 |
|
PO2/FiO2d |
|||||
|
Thiopental |
284 ± 130 |
300 ± 139 |
293 ± 132 |
285 ± 138 |
254 ± 119 |
|
Pentobarbital |
317 ± 127 |
304 ± 116 |
262 ± 125 |
211 ± 77 |
184 ± 92 |
|
Haemoglobin |
|||||
|
Thiopental |
10.9 ± 1.6 |
10.7 ± 1.3 |
11 ± 1.2 |
10.8 ± 0.9 |
10.7 ± 1.4 |
|
Pentobarbital |
10.6 ± 1.2 |
10.1 ± 1.0 |
10.4 ± 1.1 |
10.5 ± 1.1 |
10.2 ± 1.2 |
|
Temperature (°C)e |
|||||
|
Thiopental |
35.8 ± 0.5 |
34.6 ± 1.3 |
34.6 ± 3.4 |
34.9 ± 1.0 |
34.9 ± 1.0 |
|
Pentobarbital |
35.7 ± 1.0 |
34.6 ± 1.2 |
34.3 ± 1.3 |
34.4 ± 1.3 |
34.2 ± 1.1 |
|
|
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|
aCardiac output, cardiac index, peripheral venous resistance and pulmonary artery wedge pressure: the values are the mean values over 24 hours. bmBP: minimum value of the medium blood pressure during the day. cNAD: maximum dose of Noradrenaline bitartrate during the day. dPO2/FisO2: ratio of partial oxygen tension to inspired fractional oxygen tension at 8:00 am. eTemperature: value of the minimum central temperature. *P < 0.05. |
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|
Pérez-Bárcena et al. Critical Care 2008 12:R112 doi:10.1186/cc6999 |
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