Figure 1.

The changes in alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and blood urea nitrogen (BUN) after lipopolysaccharide (LPS) injection. ALT increased significantly 6 hours after LPS injection in the control group but did not change in the danaparoid sodium (DA) group; the difference was significant from 1 to 12 hours after LPS injection. Similarly, significant LDH elevation is recognized from 1 to 12 hours after LPS injection in the control group. In contrast, the level stayed almost in the normal range during the experimental period in the DA group. There was no significant difference in the peak BUN level, but the difference was significant 1 hour after LPS injection (*P < 0.05, **P < 0.01) (■: control group, □: DA group, n = 8 in each group).