Figure 2.

The changes in antithrombin (AT) activity, fibrin/fibrinogen degradation products (FDP), and fibrinogen after lipopolysaccharide (LPS) injection. AT activity decreased after LPS injection and recovered to the normal range at 24 hours in both groups. Although there was no significant difference in the bottom level, the difference was significant at 6 hours. The FDP level had already increased at 1 hour after LPS injection and decreased to 25 μg/dL in both groups at 24 hours; the difference was not significant during the time course. The fibrinogen level decreased after LPS injection and was lowest at 6 hours; the difference was significant at this time point (*P < 0.05, **P < 0.01) (■: control group, □: danaparoid sodium group, n = 8 in each group).