Table 1

Time course of haemodynamic parameters, inspiratory plateau airway pressure, arterial blood pH, PaO₂ and PaCO₂ after oleic acid injection and during a decremental PEEP trial from 20 to 0 cm H₂O.

HR (beats/min)

Mean AP (mmHg)

pH

PaO₂ (mmHg)

PaCO₂ (mmHg)

Inspiratory plateau pressure (cm H₂O)

ARDS

129 ± 3

75 ± 16

7.32 ± 0.06

52 ± 5

54 ± 5

20 ± 1

ARDS20

132 ± 4

66 ± 13

7.33 ± 0.04

172 ± 15*

54 ± 3

36 ± 3*

ARDS15

134 ± 4

73 ± 13

7.38 ± 0.02

175 ± 17*

54 ± 2

26 ± 1*

ARDS10

145 ± 3*

75 ± 9

7.28 ± 0.05

89 ± 19*

56 ± 5

23 ± 2

ARDS5

165 ± 10*

118 ± 9*

7.33 ± 0.02

52 ± 4*

59 ± 2

22 ± 2

ARDS0

153 ± 7*

101 ± 5*

7.3 ± 0.03

52 ± 4*

62 ± 3*

21 ± 2

Data are presented as mean ± standard error of the mean. Measurements were obtained 120 min after oleic acid injection at a PEEP of 5 cm H₂O (ARDS) and during a decremential PEEP trial (ARDS20, ARDS15, ARDS10, ARDS5, ARDS0). Each PEEP level was maintained for 15 min before each measurement to allow for haemodynamic and respiratory stabilisation. ARDS, acute respiratory distress syndrome; HR, heart rate; mean AP, mean systemic arterial pressure; PEEP, positive end-expiratory pressure. * p < 0.05 versus ARDS

Lambermont et al. Critical Care 2008 12:R91   doi:10.1186/cc6961