Evidence-lost to tight glycemic control?

doi:10.1186/cc7022

Critical Care
Volume 12
Issue 5

Viewing options:

Abstract
Full text
PDF (36KB)

Associated material:

Related literature:

Articles citing this article
on Google Scholar
on ISI Web of Science
on PubMed Central
Other articles by authors
on Google Scholar

Schultz MJ
Spronk PE
Abu-Hanna A
Afessa B
Gajic O

on PubMed

Schultz MJ
Spronk PE
Abu-Hanna A
Afessa B
Gajic O
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Letter

Evidence-lost to tight glycemic control?

Marcus J Schultz¹^,2^,3 , Peter E Spronk¹^,3^,4 , Ameen Abu-Hanna⁵ , Bekele Afessa⁶^,7 and Ognjen Gajic⁶^,7

¹Department of Intensive Care Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

²Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

³HERMES Critical Care Group, Amsterdam, The Netherlands

⁴Department of Intensive Care Medicine, Gelre Hospital – Location Lukas, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands

⁵Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

⁶Division of Pulmonary and Critical Care Medicine, Mayo Clinic, First Street 200 Rochester, Minnesota, MN 55905 USA

⁷Mayo Epidemiology and Translational Research in Intensive Care, Mayo Clinic, First Street 200 Rochester, Minnesota, MN 55905 USA

author email corresponding author email

Critical Care 2008, 12:430doi:10.1186/cc7022


Published:	20 October 2008

See related research by De la Rosa et al., http://ccforum.com/content/12/5/R120

First paragraph (this article has no abstract)

In recent years, the field of intensive care medicine has had the benefit of learning from two randomized controlled trials that tight glycemic control (TGC) is beneficial to critically ill patients [1,2]. No benefit was found by two other clinical trials, however, hampering implementation of TGC in daily practice [3,4]. The question arises of whether the intensive care community interprets the results of these later trials in the correct way. What are the alternative explanations for why two trials do show beneficial effects while two other trials do not, apart from the possibility that TGC may indeed not benefit critically ill patients?