Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis

doi:10.1186/cc7011

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Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis

Pierre-François Laterre^*, William L Macias, Jonathan Janes, Mark D Williams, David R Nelson, Amand RJ Girbes, Jean-François Dhainaut and Edward Abraham

* Corresponding author: Pierre-François Laterre laterre@rean.ucl.ac.be

Critical Care 2008, 12:R117 doi:10.1186/cc7011

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Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis

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Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis