Figure 6.

Adenosine deaminase 1 inhibition protects against septic shock induced by caecal ligation and puncture (CLP). Kaplan-Meier survival curves; septic shock induction by CLP resulted in a 160-hour survival rate of about 25%. In contrast, direct adenosine deaminase-1 inhibition after septic shock induction via CLP resulted in a 160-hour survival rate of about 75% (p = 0.0018). A protective effect was still present when the erythro-9-[2-hydroxyl-3-nonyl]-adenine (EHNA) treatment was delayed for four hours after CLP (55% survival, p = 0.029).