References

  1. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, the Consensus Committee: The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination.

    Am J Respir Crit Care Med 1994, 149:818-829. PubMed Abstract OpenURL

  2. Villar J, Pérez-Méndez L, López J, Belda J, Blanco J, Saralegui I, Suárez-Sipman F, López J, Lubillo S, Kacmarek RM, the HELP Network: An early PEEP/FiO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome.

    Am J Respir Crit Care Med 2007, 176:795-804. PubMed Abstract | Publisher Full Text OpenURL

  3. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD: Incidence and outcomes of acute lung injury.

    N Engl J Med 2005, 353:1685-1693. PubMed Abstract | Publisher Full Text OpenURL

  4. Villar J, Maca-Meyer N, Pérez-Méndez L, Flores C: Understanding genetic predisposition to sepsis.

    Crit Care 2004, 8:180-189. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  5. Cobb JP, O'Keefe GE: Injury research in the genomic era.

    Lancet 2004, 363:2076-2083. PubMed Abstract | Publisher Full Text OpenURL

  6. Rahim NG, Harismendy O, Topol EJ, Frazer KA: Genetic determinants of phenotypic diversity in humans.

    Genome Biology 2008, 9:215. PubMed Abstract | BioMed Central Full Text OpenURL

  7. Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW: Genetic and environmental influences on premature death in adult adoptees.

    N Engl J Med 1998, 318:727-732. OpenURL

  8. Moss M, Mannino DM: Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979 – 1996).

    Crit Care Med 2002, 30:1679-1685. PubMed Abstract | Publisher Full Text OpenURL

  9. Prows DR, Shertzer HG, Daly MJ, Sidman CL, Leikauf GD: Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice.

    Nat Genet 1997, 17:471-474. PubMed Abstract | Publisher Full Text OpenURL

  10. Nonas SA, Moreno-Vinasco L, Ma SF, Jacobson JR, Desai AA, Dudek SM, Flores C, Hassoun PM, Sam L, Ye SQ, Moitra J, Barnard J, Grigoryev DN, Lussier YA, Garcia JG: Use of consomic rats for genomic insights into ventilator-associated lung injury.

    Am J Physiol Lung Cell Mol Physiol 2007, 293:L292-302. PubMed Abstract | Publisher Full Text OpenURL

  11. Prows DR, Hafertepen AP, Winterberg AV, Gibbons WJ Jr, Wesselkamper SC, Singer JB, Hill AE, Nadeau JH, Leikauf GD: Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time.

    Am J Respir Cell Mol Biol 2008, 38:68-77. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  12. Cordell HJ, Clayton DG: Genetic association studies.

    Lancet 2005, 366:1121-1131. PubMed Abstract | Publisher Full Text OpenURL

  13. Risch N, Merikangas K: The future of genetic studies of complex human diseases.

    Science 1996, 273:1516-1517. PubMed Abstract | Publisher Full Text OpenURL

  14. The International HapMap Consortium: A second generation human haplotype map of over 3.1 million SNPs.

    Nature 2007, 449:851-861. PubMed Abstract | Publisher Full Text OpenURL

  15. Iles MM: What can genome-wide association studies tell us about the genetics of common disease?

    PLoS Genet 2008, 4:e33. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  16. Hattsersley AT, McCarthy MI: What makes a good genetic association study?

    Lancet 2005, 366:1315-1323. PubMed Abstract | Publisher Full Text OpenURL

  17. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN: Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.

    Nat Genet 2003, 33:177-182. PubMed Abstract | Publisher Full Text OpenURL

  18. Neale BM, Sham PC: The future of association studies: gene-based analysis and replication.

    Am J Hum Genet 2004, 75:353-362. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  19. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.

    Nature Genet 2000, 25:25-29. PubMed Abstract | Publisher Full Text OpenURL

  20. NCI-NHGRI Working Group on Replication in Association Studies: Replicating genotype-phenotype associations.

    Nature 2007, 447:655-660. PubMed Abstract | Publisher Full Text OpenURL

  21. Lin Z, Pearson C, Chinchilli V, Pietschmann SM, Luo J, Pison U, Floros J: Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS.

    Clin Genet 2000, 58:181-191. PubMed Abstract | Publisher Full Text OpenURL

  22. Marshall RP, Webb S, Hill MR, Humphries SE, Laurent GJ: Genetic polymorphisms associated with susceptibility and outcome in ARDS.

    Chest 2002, 121(3 Suppl):68S-69S. PubMed Abstract | Publisher Full Text OpenURL

  23. Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, Humphries SE, Hill MR, Laurent GJ: Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.

    Am J Respir Crit Care Med 2002, 166:646-650. PubMed Abstract | Publisher Full Text OpenURL

  24. Quasney MW, Waterer GW, Dahmer MK, Kron GK, Zhang Q, Kessler LA, Wunderink RG: Association between surfactant protein B +1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia.

    Crit Care Med 2004, 32:1115-1119. PubMed Abstract | Publisher Full Text OpenURL

  25. Gong MN, Wei Z, Xu LL, Miller DP, Thompson BT, Christiani DC: Polymorphism in the surfactant protein-B gene, and the risk of direct pulmonary injury and ARDS.

    Chest 2004, 125:203-211. PubMed Abstract | Publisher Full Text OpenURL

  26. Ye SQ, Simon BA, Maloney JP, Zambelli-Weiner A, Gao L, Grant A, Easley RB, McVerry BJ, Tuder RM, Standiford T, Brower RG, Barnes KC, Garcia JG: Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury.

    Am J Respir Crit Care Med 2005, 171:361-370. PubMed Abstract | Publisher Full Text OpenURL

  27. Ip WK, Chan KH, Law HK, Tso GH, Kong EK, Wong WH, To YF, Yung RW, Chow EY, Au KL, Chan EY, Lim W, Jensenius JC, Turner MW, Peiris JS, Lau YL: Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection.

    J Infect Dis 2005, 191:1697-1704. PubMed Abstract | Publisher Full Text OpenURL

  28. Sutherland AM, Walley KR, Manocha S, Russell JA: The association of interleukin 6 haplotype clades with mortality in critically ill adults.

    Arch Intern Med 2005, 165:75-82. PubMed Abstract | Publisher Full Text OpenURL

  29. Nonas SA, Finigan JH, Gao L, Garcia JG: Functional genomic insights into acute lung injury: role of ventilators and mechanical stress.

    Proc Am Thorac Soc 2005, 2:188-194. PubMed Abstract | Publisher Full Text OpenURL

  30. Gong MN, Zhou W, Williams PL, Thompson BT, Pothier L, Boyce P, Christiani DC: -308 and TNFB polymorphisms in acute respiratory distress syndrome.

    Eur Respir J 2005, 26:382-389. PubMed Abstract | Publisher Full Text OpenURL

  31. Medford AR, Keen LJ, Bidwell JL, Millar AB: Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome.

    Thorax 2005, 60:244-248. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  32. Gao L, Grant A, Halder I, Brower R, Sevransky J, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Shriver MD, Ingersoll R, Scott AF, Beaty TH, Moitra J, Ma SF, Ye SQ, Barnes KC, Garcia JG: Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.

    Am J Respir Cell Mol Biol 2006, 34:487-495. PubMed Abstract | Publisher Full Text OpenURL

  33. Gong MN, Thompson BT, Williams PL, Zhou W, Wang MZ, Pothier L, Christiani DC: Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome.

    Eur Respir J 2006, 27:674-681. PubMed Abstract | Publisher Full Text OpenURL

  34. Jerng JS, Yu CJ, Wang HC, Chen KY, Cheng SL, Yang PC: Polymorphism of the angiotensin-converting enzyme gene affects the outcome of acute respiratory distress syndrome.

    Crit Care Med 2006, 34:1001-1006. PubMed Abstract | Publisher Full Text OpenURL

  35. Gao L, Flores C, Fan-Ma S, Miller EJ, Moitra J, Moreno L, Wadgaonkar R, Simon B, Brower R, Sevransky J, Tuder RM, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Ye SQ, Barnes KC, Garcia JG: Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations.

    Transl Res 2007, 150:18-29. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  36. Bajwa EK, Yu CL, Gong MN, Thompson BT, Christiani DC: Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome.

    Crit Care Med 2007, 35:1290-1295. PubMed Abstract | Publisher Full Text OpenURL

  37. Marzec JM, Christie JD, Reddy SP, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Yamamoto T, Yamamoto M, Cho HY, Kleeberger SR: Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury.

    FASEB J 2007, 21:2237-2246. PubMed Abstract | Publisher Full Text OpenURL

  38. Villar J, Pérez-Méndez L, Flores C, Maca-Meyer N, Espinosa E, Muriel A, Sangüesa R, Blanco J, Muros M, Kacmarek RM, the GRECIA and GEN-SEP Groups: A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis.

    Crit Care Med 2007, 35:2292-2297. PubMed Abstract OpenURL

  39. Gong MN, Zhou W, Williams PL, Thompson BT, Pothier L, Christiani DC: Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.

    Crit Care Med 2007, 35:48-56. PubMed Abstract | Publisher Full Text OpenURL

  40. Adamzik M, Frey U, Sixt S, Knemeyer L, Beiderlinden M, Peters J, Siffert W: ACE I/D but not AGT (-6)A/G polymorphism is a risk factor for mortality in ARDS.

    Eur Respir J 2007, 29:482-488. PubMed Abstract | Publisher Full Text OpenURL

  41. Zhai R, Zhou W, Gong MN, Thompson BT, Su L, Yu C, Kraft P, Christiani DC: Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians.

    Crit Care Med 2007, 35:893-898. PubMed Abstract | Publisher Full Text OpenURL

  42. Adamzik M, Frey UH, Rieman K, Sixt S, Beiderlinden M, Siffert W, Peters J: Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome.

    Intensive Care Med 2007, 33:1199-1203. PubMed Abstract | Publisher Full Text OpenURL

  43. Zhai R, Gong MN, Zhou W, Thompson TB, Kraft P, Su L, Christiani DC: Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS.

    Thorax 2007, 62:718-722. PubMed Abstract | Publisher Full Text OpenURL

  44. Arcaroli J, Sankoff J, Liu N, Allison DB, Maloney J, Abraham E: Association between urokinase haplotypes and outcome from infection-associated acute lung injury.

    Intensive Care Med 2008, 34:300-307. PubMed Abstract | Publisher Full Text OpenURL

  45. Christie JD, Ma SF, Aplenc R, Li M, Lanken PN, Shah CV, Fuchs B, Albelda SM, Flores C, Garcia JG: Variation in the MYLK gene is associated with development of acute lung injury after major trauma.

    Crit Care Med 2008, 36:2794-2800. PubMed Abstract | Publisher Full Text OpenURL

  46. Garcia-Laorden MI, Sole-Violan J, Rodriguez de Castro F, Aspa J, Briones ML, Garcia-Saavedra A, Rajas O, Blanquer J, Caballero-Hidalgo A, Marcos-Ramos JA, Hernandez-Lopez J, Rodriguez-Gallego C: Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults.

    J Allergy Clin Immunol 2008, 122:368-374. PubMed Abstract | Publisher Full Text OpenURL

  47. Flores C, Ma SF, Maresso K, Wade M, Villar J, Garcia JGN: An IL6 gene-wide haplotype is associated with susceptibility to acute lung injury.

    Transl Res 2008, 152:11-17. PubMed Abstract | Publisher Full Text OpenURL

  48. Schroeder O, Schulte KM, Schroeder J, Ekkernkamp A, Laun RA: The -1082 interleukin-10 polymorphism is associated with acute respiratory failure after major trauma: a prospective cohort study.

    Surgery 2008, 143:233-242. PubMed Abstract | Publisher Full Text OpenURL

  49. Adamzik M, Frey UH, Riemann K, Sixt S, Lehmann N, Siffert W, Peters J: Factor V Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome.

    Crit Care Med 2008, 36:1776-1779. PubMed Abstract | Publisher Full Text OpenURL

  50. Yu W, Gwinn M, Clyne M, Yesupriya A, Khoury MJ: A navigator for human genome epidemiology.

    Nat Genet 2008, 40:124-125. PubMed Abstract | Publisher Full Text OpenURL

  51. Wurfel MM: Microarray-based analysis of ventilator-induced lung injury.

    Proc Am Thorac Soc 2007, 4:77-84. PubMed Abstract | Publisher Full Text OpenURL

  52. Zondervan KT, Cardon LR: The complex interplay among factors that influence allelic association.

    Nat Rev Genet 2004, 5:89-100. PubMed Abstract | Publisher Full Text OpenURL

  53. Villar J, Flores C, Pérez-Méndez L, Maca-Meyer N, Espinosa E, Blanco J, Sangüesa R, Muriel A, Tejera P, Muros M, Slutsky AS: Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome.

    Intensive Care Med 2008, 34:488-495. PubMed Abstract | Publisher Full Text OpenURL

  54. Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG: Orthologous gene-expression profiling in multi-species models: search for candidate genes.

    Genome Biology 2004, 5:R34. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  55. Meduri GU, Headley S, Kohler G, Stentz F, Tolley E, Umberger R, Leeper K: Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time.

    Chest 1995, 107:1062-1073. PubMed Abstract | Publisher Full Text OpenURL

  56. ENCODE Project Consortium: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

    Nature 2007, 447:799-816. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  57. Fan JB, Chee MS, Gunderson KL: Highly parallel genomic assays.

    Nat Rev Genet 2006, 7:632-644. PubMed Abstract | Publisher Full Text OpenURL