Table 2

Oxygenation and hemodynamic parameters

SB

BL-ALI

Treatment

Lung injury

Time

Injury type

Mode

Inter-action

PaO₂/FiO₂, mm Hg

HCl

+

132 ± 18

150 ± 50

^a

TM^a

-

151 ± 58

137 ± 104

OA

+

145 ± 51

184 ± 116

-

146 ± 68

109 ± 46

HR, beats per minute

HCl

+

96 ± 12

112 ± 11

^a

^a

-

100 ± 22

108 ± 20

OA

+

102 ± 11

110 ± 23

-

112 ± 18

119 ± 23

MAP, mm Hg

HCl

+

79 ± 8

86 ± 9^b

^a

^a

-

77 ± 23

92 ± 13^b

OA

+

93 ± 12^d

97 ± 13^{b, d}

-

101 ± 10^d

104 ± 15^{b, d}

CVP, mm Hg

HCl

+

11 ± 2

10 ± 2^b

^a

-

12 ± 3

12 ± 2^b

OA

+

15 ± 2^d

14 ± 2^{b, d}

-

15 ± 4^d

14 ± 3^{b, d}

SVR, dyne-second/cm⁵

HCl

+

1,335 ± 198

1,057 ± 191^b

^a

^a

^a

-

1,255 ± 429

1,072 ± 333^b

OA

+

1,513 ± 344

1,281 ± 388^b

-

1,490 ± 384

1,060 ± 206^b

CO, L/minute

HCl

+

4.1 ± 0.3

4.6 ± 0.8

^a

^a

-

4.2 ± 0.9^c

4.8 ± 0.9^c

OA

+

4.2 ± 0.7

4.3 ± 0.8

-

4.8 ± 0.8^c

5.5 ± 0.7^c

DO₂, mL/minute

HCl

+

323 ± 28

393 ± 71

^a

^a

-

336 ± 63

369 ± 89

OA

+

335 ± 89

360 ± 48

-

408 ± 80

430 ± 118

VO₂, mL/minute

HCl

+

181 ± 31

172 ± 33

^a

^a

-

169 ± 23

172 ± 32

OA

+

159 ± 27^c

147 ± 34^c

-

154 ± 32^c

167 ± 42^c

Shunt < 0.005, %Q_T

HCl

+

27.1 ± 6.2

23.3 ± 12.7

^a

TM^a

-

27.7 ± 7.9

37.4 ± 17.4^b

OA

+

32.6 ± 18.9

26.0 ± 17.9

-

32.4 ± 12.4

47.2 ± 17.1^b

Dead space > 100, %Ve

HCl

+

33.0 ± 5.5

45.1 ± 11.8

^a

-

34.4 ± 5.9

38.7 ± 3.9

OA

+

39.1 ± 6.6

44.9 ± 12.8

-

39.0 ± 6.0

46.2 ± 12.2

Pre-acute lung injury (ALI) (Table S1 in additional data file) was tested only against baseline ALI (BL-ALI). Post hoc testing was always performed if a significant F ratio for a factor or the interaction of factors was obtained by repeated measures analysis of variance (^aP < 0.05), but only significant differences are marked: ^bP < 0.05 for within-group differences (BL-ALI versus Treatment), ^cP < 0.05 for between-group differences (HCl-ALI versus OA-ALI), and ^dP < 0.05 for between-group differences (PCV + SB versus PCV – SB) (post hoc Tukey multiple comparison test). +, pressure-controlled ventilation with maintained spontaneous breathing; -, pressure-controlled ventilation without spontaneous breathing; CO, cardiac output; CVP, central venous pressure; DO₂, oxygen delivery; HCl, hydrochloric acid-induced acute lung injury; HCl-ALI, hydrochloric acid-induced acute lung injury; HR, heart rate; M, mode; MAP, mean arterial pressure; OA, oleic acid-induced acute lung injury; OA-ALI, oleic acid-induced acute lung injury; PaO₂/FiO₂, arterial partial pressure of oxygen/inspiratory fraction of oxygen; PCV + SB, pressure-controlled ventilation with spontaneous breathing; PCV – SB, pressure-controlled ventilation without spontaneous breathing; %Q_T, percentage of cardiac output; SB, spontaneous breathing; SVR, systemic vascular resistance; T, time; , ventilation/perfusion (ratio); %Ve, percentage of minute ventilation; VO₂, oxygen consumption.

Varelmann et al. Critical Care 2008 12:R135   doi:10.1186/cc7108