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Airway pressures, respiratory system mechanics, and heart rate before and up to 12 hours after salmeterol administration |
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| Baseline |
15 minutes |
30 minutes |
1 hour |
2 hours |
3 hours |
4 hours |
6 hours |
8 hours |
10 hours |
12 hours |
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|
|
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| Ppk |
35.0 ± 5.1 |
33.0 ± 5.1a |
31.4 ± 5.0a |
30.8 ± 4.8a |
30.6 ± 4.9a |
30.4 ± 4.9a |
30.6 ± 4.5a |
30.7 ± 4.6a |
31.4 ± 4.5a |
32.3 ± 4.5a |
33.2 ± 4.5a |
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|
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| P1 |
22.3 ± 4.1 |
21.4 ± 4.3a |
20.7 ± 4.4a |
20.5 ± 4.2a |
20.4 ± 4.4a |
20.2 ± 4.1a |
20.3 ± 3.8a |
20.4 ± 3.9a |
20.5 ± 3.6a |
20.9 ± 3.7a |
21.4 ± 3.7a |
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| P2 |
16.7 ± 3.1 |
15.8 ± 2.8a |
15.3 ± 3.1a |
15.1 ± 2.9a |
15.0 ± 3.1a |
14.9 ± 3.2a |
14.9 ± 2.8a |
15.0 ± 2.8a |
15.2 ± 2.7a |
15.5 ± 2.6a |
16.0 ± 2.7 |
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| PEEPi |
7.1 ± 1.6 |
6.2 ± 1.7a |
5.5 ± 1.9a |
5.2 ± 1.8a |
5.2 ± 1.8a |
5.1 ± 1.8a |
5.1 ± 1.8a |
5.2 ± 1.9a |
5.4 ± 1.8a |
5.7 ± 1.8a |
6.2 ± 1.8a |
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| Rrs |
25.4 ± 4.1 |
23.8 ± 4.4a |
22.3 ± 4.1a |
21.7 ± 3.6a |
21.6 ± 3.6a |
21.5 ± 3.5a |
21.8 ± 3.3a |
21.6 ± 3.6a |
22.5 ± 4.2a |
23.2 ± 4.1a |
23.9 ± 3.8a |
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| Rint |
17.6 ± 3.7 |
16.1 ± 4.0a |
14.9 ± 3.6a |
14.3 ± 3.1a |
14.2 ± 3.0a |
14.2 ± 3.0a |
14.3 ± 3.0a |
14.3 ± 3.0a |
15.1 ± 3.7a |
16.0 ± 3.9a |
16.4 ± 3.4a |
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| ΔR |
7.7 ± 2.2 |
7.7 ± 2.5 |
7.5 ± 2.2 |
7.5 ± 2.2 |
7.5 ± 2.2 |
7.3 ± 1.9 |
7.5 ± 1.9 |
7.3 ± 2.0 |
7.3 ± 2.0 |
7.2 ± 2.0 |
7.5 ± 2.1 |
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| Cst, rs |
54.3 ± 9.0 |
54.2 ± 9.0 |
53.1 ± 7.4 |
52.3 ± 7.4 |
53.0 ± 7.4 |
53.3 ± 7.5 |
53.1 ± 7.7 |
52.7 ± 6.7 |
52.8 ± 6.3 |
52.2 ± 5.8 |
52.2 ± 5.8 |
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| HR |
74.8 ± 8.5 |
75.0 ± 7.3 |
74.5 ± 6.8 |
75.0 ± 7.2 |
74.5 ± 6.2 |
73.9 ± 7.7 |
73.5 ± 8.7 |
73.1 ± 9.6 |
73.8 ± 8.8 |
74.8 ± 11.0 |
73.4 ± 10.2 |
|
Values are presented as mean ± standard deviation. aSignificantly different from baseline values (P < 0.05, Wilcoxon signed rank test). bRespiratory system mechanics were measured while the patients were on volume control with square wave inspiratory flow-time profile. Crs, st, end-inspiratory static compliance of the respiratory system (mL/cm H2O); HR, heart rate (beats per minute); P1, airway pressure at the point of zero flow (cm H2O); P2, plateau pressure (cm H2O); PEEPi, intrinsic positive end-expiratory pressure (cm H2O); Ppk, peak airway pressure (cm H2O); Rint, minimum inspiratory resistance (cm H2O/L per second); Rrs, maximum inspiratory resistance (cm H2O/L per second); ΔR, difference between maximum inspiratory resistance and minimum inspiratory resistance (cm H2O/L per second). | |||||||||||
Malliotakis et al. Critical Care 2008 12:R140 doi:10.1186/cc7117 |
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