Figure 1.

Experimental design. Animals in all treatment groups received induction of acute necrotising pancreatitis at time point 0. In experimental group 1, animals were euthanased at 24 hours. Prophylactic antibiotic treatment (starting six hours after induction of pancreatitis) was evaluated versus no antibiotic treatment. In a second experimental group, animal were euthanased at 72 hours. Meropenem therapy on-demand (starting at 24 hours after induction of pancreatitis) was compared with prophylactic treatment and controls.