Figure 4.

Bacterial superinfection at 72 hours. Both prophylactic and therapeutic antibiotic treatment reduced bacterial infection of blood, pancreatic tissue, mesenteric lymph nodes of small bowel (LN Sm.bo.) and colon (LN Colon). Compared with the control group without antibiotic treatment, prophylactic treatment reduced significantly bacterial infection of blood (p = 0.041), ascites (p = 0.039), pancreatic tissue (p < 0.001), mesenteric lymph nodes of small bowel (p = 0.010) and colon (p = 0.001). Compared with this, on-demand antibiotic treatment only reduced pancreatic superinfection and infection of mesenteric lymph nodes of the colon significantly (p = 0.026 and p = 0.039, respectively).