|
Effects of recombinant human activated protein C on oleic acid-induced changes in systemic and pulmonary hemodynamics in awake sheep |
|||
| Time |
|||
|
|
|||
| 0 hours |
1 hour |
2 hours |
|
|
|
|||
| MAP, mm Hg |
|||
| Sham |
99 ± 4 |
99 ± 5 |
98 ± 5 |
| OA |
94 ± 3 |
102 ± 2 |
104 ± 3†a |
| OA+rhAPC |
94 ± 3 |
99 ± 3 |
98 ± 4 |
| CI, L/min per m2 |
|||
| Sham |
5.8 ± 0.2 |
5.5 ± 0.2 |
5.3 ± 0.2 |
| OA |
6.3 ± 0.3 |
4.8 ± 0.4a |
4.7 ± 0.5 |
| OA+rhAPC |
5.8 ± 0.4 |
4.5 ± 0.3a |
4.2 ± 0.3a |
| SVRI, dynessecm2/cm5 |
|||
| Sham |
1,627 ± 58 |
1,497 ± 97 |
1,479 ± 153 |
| OA |
1,231 ± 65 |
1,870 ± 320 |
1,696 ± 130a |
| OA+rhAPC |
1,326 ± 69 |
1,734 ± 132a |
2,085 ± 220a |
| PAOP, mm Hg |
|||
| Sham |
9 ± 0 |
8 ± 0 |
9 ± 1 |
| OA |
9 ± 0 |
13 ± 1a |
13 ± 1a |
| OA+rhAPC |
8 ± 0 |
12 ± 1a |
11 ± 1a |
| Pmo, mm Hg |
|||
| Sham |
7 ± 0 |
7 ± 0 |
7 ± 0 |
| OA |
7 ± 1 |
10 ± 1 |
12 ± 1a |
| OA+rhAPC |
7 ± 1 |
11 ± 1a |
10 ± 1a |
| PVRI, dynessecm2/cm5 |
|||
| Sham |
112 ± 12 |
134 ± 15 |
136 ± 9 |
| OA |
104 ± 8 |
333 ± 59a |
300 ± 39a |
| OA+rhAPC |
132 ± 8b |
233 ± 25a |
231 ± 28a |
| HR, beats per minute |
|||
| Sham |
104 ± 6 |
103 ± 6 |
93 ± 6 |
| OA |
109 ± 5 |
106 ± 12 |
104 ± 12 |
| OA+rhAPC |
99 ± 6 |
95 ± 8 |
84 ± 5a |
| SVI, mL/beat per m2 |
|||
| Sham |
58 ± 4 |
55 ± 2 |
60 ± 6 |
| OA |
59 ± 5 |
48 ± 5 |
47 ± 6 |
| OA+rhAPC |
58 ± 5 |
49 ± 4a |
50 ± 4a |
| LVSWI, gm/m2 |
|||
| Sham |
70 ± 4 |
67 ± 3 |
71 ± 2 |
| OA |
69 ± 8 |
57 ± 5 |
59 ± 8 |
| OA+rhAPC |
68 ± 3 |
57 ± 4 |
59 ± 5 |
| RVSWI, gm/m2 |
|||
| Sham |
11 ± 1 |
11 ± 0 |
12 ± 1 |
| OA |
12 ± 1 |
17 ± 2a |
15 ± 1 |
| OA+rhAPC |
11 ± 1 |
15 ± 1 |
14 ± 1 |
|
Values are presented as mean ± standard error of the mean. Sham refers to sham-operated sheep (n = 6), OA refers to sheep receiving infusion of oleic acid (n = 8), and OA+rhAPC refers to sheep receiving oleic acid and recombinant human activated protein C (n = 8). aP < 0.05 from t = 0 hours. bP < 0.05 between OA and the OA+rhAPC groups. CI, cardiac index; HR, heart rate; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; PAOP, pulmonary artery occlusion pressure; Pmo, pulmonary micro-occlusion pressure; PVRI, pulmonary vascular resistance index; RVSWI, right ventricular stroke work index; SVI, stroke volume index; SVRI, systemic vascular resistance index. | |||
Waerhaug et al. Critical Care 2008 12:R146 doi:10.1186/cc7128 |
|||