Table 2

Effects of recombinant human activated protein C on oleic acid-induced changes in oxygen-related variables and body temperature in awake sheep

Time

0 hours

2 hours

SaO₂, percentage

Sham

99 ± 0

99 ± 0

OA

98 ± 1

88 ± 5^a

OA+rhAPC

99 ± 1

97 ± 1

AaPO₂, mm Hg

Sham

29 ± 8

27 ± 7

OA

33 ± 8

54 ± 10^a

OA+rhAPC

28 ± 13

34 ± 12^b

DO₂, mL/min per m²

Sham

818 ± 78

705 ± 53

OA

825 ± 39

600 ± 56^a

OA+rhAPC

805 ± 71

566 ± 31^a

VO₂, mL/min per m²

Sham

334 ± 38

258 ± 41

OA

316 ± 34

278 ± 110

OA+rhAPC

316 ± 75

214 ± 51^a

O₂ER, percentage

Sham

38 ± 5

34 ± 3

OA

38 ± 2

47 ± 4

OA+rhAPC

40 ± 1

39 ± 2

PaCO₂, kPa

Sham

37 ± 2

35 ± 2

OA

36 ± 1

41 ± 4

OA+rhAPC

35 ± 1

40 ± 2

Qs/Qt

Sham

0.042 ± 0.009

0.062 ± 0.018

OA

0.062 ± 0.014

0.246 ± 0.080^a

OA+rhAPC

0.045 ± 0.016

0.087 ± 0.027

Arterial pH

Sham

7.51 ± 0.02

7.52 ± 0.01

OA

7.50 ± 0.01

7.44 ± 0.02

OA+rhAPC

7.51 ± 0.01

7.50 ± 0.02

Hemoglobin, g/dL

Sham

10 ± 1

10 ± 0

OA

10 ± 0

11 ± 0

OA+rhAPC

10 ± 0

10 ± 0

Body temperature, °C

Sham

40.0 ± 0.2

39.5 ± 0.4

OA

39.3 ± 0.3

39.3 ± 0.3

OA+rhAPC

39.4 ± 0.1

39.3 ± 0.1

Values are presented as mean ± standard error of the mean. Sham refers to the sham-operated sheep (n = 6), OA refers to sheep receiving infusion of oleic acid (n = 8), and OA+rhAPC refers to sheep receiving oleic acid and recombinant human activated protein C (n = 8). ^aP < 0.05 from t = 0 hours. ^bP < 0.05 between OA and the OA+rhAPC groups. AaPO₂, alveolar-arterial oxygen tension difference; DO₂, oxygen delivery index; O₂ER, oxygen extraction ratio; PaCO₂ arterial partial pressure of carbon dioxide; Qs/Qt, venous admixture; SaO₂, arterial oxygen saturation; VO₂, oxygen consumption index.

Waerhaug et al. Critical Care 2008 12:R146   doi:10.1186/cc7128