Table 2

Effects of recombinant human activated protein C on oleic acid-induced changes in oxygen-related variables and body temperature in awake sheep

Time

0 hours
 2 hours
SaO2, percentage

     Sham
 99 ± 0
 99 ± 0
     OA
 98 ± 1
 88 ± 5a
     OA+rhAPC
 99 ± 1
 97 ± 1
AaPO2, mm Hg

     Sham
 29 ± 8
 27 ± 7
     OA
 33 ± 8
 54 ± 10a
     OA+rhAPC
 28 ± 13
 34 ± 12b
DO2, mL/min per m2

     Sham
 818 ± 78
 705 ± 53
     OA
 825 ± 39
 600 ± 56a
     OA+rhAPC
 805 ± 71
 566 ± 31a
VO2, mL/min per m2

     Sham
 334 ± 38
 258 ± 41
     OA
 316 ± 34
 278 ± 110
     OA+rhAPC
 316 ± 75
 214 ± 51a
O2ER, percentage

     Sham
 38 ± 5
 34 ± 3
     OA
 38 ± 2
 47 ± 4
     OA+rhAPC
 40 ± 1
 39 ± 2
PaCO2, kPa

     Sham
 37 ± 2
 35 ± 2
     OA
 36 ± 1
 41 ± 4
     OA+rhAPC
 35 ± 1
 40 ± 2
Qs/Qt

     Sham
 0.042 ± 0.009
 0.062 ± 0.018
     OA
 0.062 ± 0.014
 0.246 ± 0.080a
     OA+rhAPC
 0.045 ± 0.016
 0.087 ± 0.027
Arterial pH

     Sham
 7.51 ± 0.02
 7.52 ± 0.01
     OA
 7.50 ± 0.01
 7.44 ± 0.02
     OA+rhAPC
 7.51 ± 0.01
 7.50 ± 0.02
Hemoglobin, g/dL

     Sham
 10 ± 1
 10 ± 0
     OA
 10 ± 0
 11 ± 0
     OA+rhAPC
 10 ± 0
 10 ± 0
Body temperature, °C

     Sham
 40.0 ± 0.2
 39.5 ± 0.4
     OA
 39.3 ± 0.3
 39.3 ± 0.3
     OA+rhAPC
 39.4 ± 0.1
 39.3 ± 0.1

Values are presented as mean ± standard error of the mean. Sham refers to the sham-operated sheep (n = 6), OA refers to sheep receiving infusion of oleic acid (n = 8), and OA+rhAPC refers to sheep receiving oleic acid and recombinant human activated protein C (n = 8). aP < 0.05 from t = 0 hours. bP < 0.05 between OA and the OA+rhAPC groups. AaPO2, alveolar-arterial oxygen tension difference; DO2, oxygen delivery index; O2ER, oxygen extraction ratio; PaCO2 arterial partial pressure of carbon dioxide; Qs/Qt, venous admixture; SaO2, arterial oxygen saturation; VO2, oxygen consumption index.

Waerhaug et al. Critical Care 2008 12:R146   doi:10.1186/cc7128