Table 2

Univariate and multivariate Cox regression analysis

Univariate

Multivariate

Variables

HR

95% CI

p value

HR

95% CI

P value

Age (years)

1.528

0.694 to 3.364

0.288

Gender (m/f)

1.007

0.983 to 1.031

0.577

Sepsis (yes/no)

2.688

0.918 to 7.874

0.072

1.004

0.154 to 6.553

0.997

MAP (mmHg)

0.981

0.954 to 1.009

0.186

Heart rate (bpm)

0.995

0.976 to 1.014

0.583

Noradrenaline (μg/kg/min)

1.433

0.695 to 2.954

0.330

FiO₂ (%)

1.002

0.980 to 1.025

0.873

PaO₂/FiO₂

1.001

0.997 to 1.005

0.737

CRP (mg/L)

0.998

0.995 to 1.002

0.364

Lactate (mmol/L)

1.105

1.029 to 1.185

0.006*

1.064

0.986 to 1.148

0.111

APACHE II score

1.060

1.012 to 1.110

0.013*

1.040

0.985 to 1.099

0.154

SOFA score

1.107

1.006 to 1.219

0.038*

1.073

0.971 to 1.185

0.167

VEGF (pg/ml)

1.000

0.997 to 1.004

0.962

Ang-1 (ng/ml)

1.010

0.918 to 1.111

0.840

Ang-2 (ng/ml)^a

1.034

1.013 to 1.056

0.001*

1.033

1.012 to 1.055

0.002*

Ang-2 (log10)^a

4.383

1.628 to 11.802

0.003*

4.284

1.627 to 11.281

0.003*

Ang-2/Ang-1 (log10)^a

2.630

1.207 to 5.729

0.015*

2.384

1.061 to 5.360

0.036* ^b

*p < 0.05.

^a tested separately from each other;

^b In this model APACHE II remained significant in the multivariate model (p = 0.039).

Ang = Angiopoietin; APACHE II = Acute Physiology and Chronic Health Evaluation II; CI = confidence interval; CRP = C-reactive protein; f = female; FiO₂ = fraction of inspired oxygen; HR = heart rate; m = male; MAP = mean arterial pressure; PaO₂ = partial pressure of oxygen in arterial blood; SOFA = Sequential Organ Failure Assessment; VEGF = vascular endothelial growth factor.

Kümpers et al. Critical Care 2008 12:R147   doi:10.1186/cc7130